Exephin 1 gm/vial (IM Injection)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ceftriaxone sodium |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Lower respiratory tract infections
- Acute Bacterial Otitis Media
- Skin and skin structure infections
- Urinary tract infections
- Gonorrhea
- Bacterial Septicemia
- Bone and joint infections
- Meningitis
- Prevention of postoperative infections
- Perioperative prophylaxis of infections associated with surgery
Pharmacology
Ceftriaxone is a 3rd generation broad-spectrum parenteral cephalosporin antibiotic with potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. It kills bacteria by interfering with the synthesis of the bacterial cell wall.
Dosage
- Adult dose: 1 to 2 gm by intravenous or intramuscular administration once a day
- Children's dose: 50 to 75 mg/kg intravenous or intramuscular administration once a day
Administration
- Preparation for Intramuscular Injection:
- 250 mg or 500 mg Ceftriaxone dissolved in Lidocaine HCI 1% injection
- 1 g Ceftriaxone in 3.5 ml of Lidocaine HCI 1% injection
- Preparation for Intravenous Injection:
- 250 mg or 500 mg Ceftriaxone dissolved in Water for injection
- 1 g Ceftriaxone in 10 ml of Water for injection USP
- 2 g Ceftriaxone in 20 ml of Water for injection
Interaction
No drug interactions reported
Contraindications
Not to be given to patients with a history of hypersensitivity to cephalosporin antibiotics
Side Effects
- Gastro-intestinal effects
- Cutaneous reactions
- Hematologic reactions
- Hepatic reactions
- CNS reactions
- Local phlebitis rare following intravenous administration
Pregnancy & Lactation
Safety in human pregnancy not established. Use in pregnancy only if absolutely indicated. Exercise caution when administered to a lactating mother.
Precautions & Warnings
- Potential for anaphylactic shock
- Shadows suggesting sludge have been detected by sonograms of the gallbladder
- Blood picture should be checked during prolonged treatment
Use in Special Populations
Must not be given to neonates if premature and newborn (up to 28 days of age)
Overdose Effects
No specific antidote. Treatment should be symptomatic.
Therapeutic Class
Third generation Cephalosporins
Storage Conditions
Store in a cool, dry place (below 30°C), away from light & moisture. Keep out of the reach of children.