G-Ceftriax 250 mg/vial (IM Injection)

250 mg vial: ৳ 50.00

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Gonoshasthaya pharma ltd
Also available as
G ceftriax 500 mg injection G ceftriax 1 gm injection G ceftriax 250 mg injection G ceftriax 500 mg injection G ceftriax 1 gm injection G ceftriax 2 gm injection

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

  • Broad-spectrum parenteral cephalosporin antibiotic
  • Bactericidal activity against a wide range of Gram-positive and Gram-negative organisms
  • Interferes with the synthesis of the bacterial cell wall
  • Relatively long plasma elimination half-life of about 6 to 9 hours

Dosage

  • 1 to 2 gm dose for adults by intravenous or intramuscular administration once a day or in equally divided doses twice a day
  • 250 mg IM as a single dose for uncomplicated gonococcal infections
  • 1 g IV as a single dose 30 to 120 minutes before surgery for surgical prophylaxis
  • 50 to 75 mg/kg dose for infants and children (01 month or older) by intravenous or intramuscular administration once a day

Administration

  • Preparation of solutions for intramuscular/intravenous injections
  • Injection should be administered over 2-4 minutes
  • Patient tolerance test should be checked before starting treatment through Ceftriaxone injection

Interaction

  • No drug interactions reported

Contraindications

  • Not to be given to patients with a history of hypersensitivity to cephalosporin antibiotics

Side Effects

  • Gastro-intestinal effects including diarrhea, nausea and vomiting, stomatitis and glossitis
  • Cutaneous reactions including rash, pruritus, urticaria, edema, and erythema multiforme
  • Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia, and neutropenia
  • Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
  • CNS reactions including nervousness, confusion, sleep disturbances, headache, hyperactivity, convulsion, hypertonia, and dizziness
  • Local phlebitis occurs rarely following intravenous administration

Pregnancy & Lactation

  • Safety in human pregnancy not established
  • Caution should be exercised when administered to a lactating mother

Precautions & Warnings

  • Anaphylactic shock cannot be ruled out
  • Shadows suggesting sludge have been detected by sonograms of the gallbladder
  • Blood picture should be checked at regular intervals during prolonged treatment

Use in Special Populations

  • Must not be given to neonates if premature and newborn (up to 28 days of age)

Overdose Effects

  • No specific antidote
  • Treatment of overdosage should be symptomatic

Therapeutic Class

  • Third generation Cephalosporins

Storage Conditions

  • Store in a cool, dry place (below 30°C), away from light & moisture, Keep out of the reach of children

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