G-Ceftriax 1 gm/vial (IM Injection)

1 gm vial: ৳ 120.00

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Gonoshasthaya pharma ltd
Also available as
G ceftriax 250 mg injection G ceftriax 500 mg injection G ceftriax 250 mg injection G ceftriax 500 mg injection G ceftriax 1 gm injection G ceftriax 2 gm injection

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

  • Broad-spectrum parenteral cephalosporin antibiotic
  • Bactericidal activity against a wide range of Gram-positive and Gram-negative organisms
  • Interferes with the synthesis of the bacterial cell wall
  • High degree of stability in the presence of beta lactamases
  • Relatively long plasma elimination half-life of about 6 to 9 hours
  • Not metabolized in the body
  • Highly protein bound (95%)

Dosage

  • Adult:
    • 1 to 2 gm by intravenous or intramuscular administration once a day
    • Maximum dose: 4 gm/day
  • Uncomplicated gonococcal infections: 250 mg IM as a single dose
  • Surgical prophylaxis: 1 g IV as a single dose 30 to 120 minutes before surgery
  • Infants and Children (01 month or older):
    • 50 to 75 mg/kg intravenous or intramuscular administration once a day
    • Maximum dose: 2 gm/day
  • Duration of therapy: Continue for more than 2 days after signs and symptoms of infection have disappeared

Administration

  • Preparation of Solutions for Intramuscular / Intravenous Injections
  • Injection should be administered over 2-4 minutes
  • Use of freshly reconstituted solution is recommended
  • Maintains potency for at least 6 hours at room temperature or 24 hours at 5°C

Interaction

No drug interactions reported

Contraindications

Hypersensitivity to cephalosporin antibiotics

Side Effects

  • Gastro-intestinal effects including diarrhea, nausea and vomiting, stomatitis and glossitis
  • Cutaneous reactions including rash, pruritus, urticaria, edema and erythema multiforme
  • Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia and neutropenia
  • Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
  • CNS reactions including nervousness, confusion, sleep disturbances, headache, hyperactivity, convulsion, hypertonia and dizziness
  • Local phlebitis occurs rarely following intravenous administration

Pregnancy & Lactation

Safety in human pregnancy has not been established. Low concentrations excreted in human milk

Precautions & Warnings

  • Anaphylactic shock cannot be ruled out
  • Shadows suggesting sludge have been detected by sonograms of the gallbladder
  • Blood picture should be checked at regular intervals during prolonged treatment

Use in Special Populations

Must not be given to neonates if premature and newborn (up to 28 days of age)

Overdose Effects

No specific antidote. Treatment should be symptomatic

Therapeutic Class

Third generation Cephalosporins

Storage Conditions

Store in a cool, dry place (below 30°C), away from light & moisture. Keep out of the reach of children

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