Imacef 2 gm/vial (IV Injection)

2 gm vial: ৳ 400.00

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company General pharmaceuticals ltd
Also available as
Imacef 500 mg injection Imacef 1 gm injection

Indications

  • Lower respiratory tract infections
  • Acute bacterial otitis media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

  • Broad-spectrum parenteral cephalosporin antibiotic
  • Bactericidal activity against wide range of Gram-positive and Gram-negative organisms
  • Interferes with synthesis of bacterial cell wall
  • High stability in presence of beta lactamases
  • Long plasma elimination half-life of 6 to 9 hours
  • Not metabolized in the body
  • Highly protein bound (95%)
  • Excreted in urine and bile/feces

Dosage

  • Usual adult dose: 1 to 2 gm by intravenous or intramuscular administration once a day
  • Maximum adult dose: 4 gm/day
  • Usual pediatric dose: 50 to 75 mg/kg intravenous or intramuscular administration once a day
  • Maximum pediatric dose: 2 gm/day
  • Duration of therapy: 4 to 14 days, longer in complicated infections

Administration

  • Preparation of solutions for intramuscular/intravenous injections
  • Recommended injection over 2-4 minutes
  • Freshly reconstituted solution recommended

Interaction

  • No reported drug interactions

Contraindications

  • History of hypersensitivity to cephalosporin antibiotics

Side Effects

  • Gastro-intestinal effects including diarrhea, nausea and vomiting
  • Cutaneous reactions including rash, pruritus, urticaria
  • Hematologic reactions including eosinophilia, thrombocytopenia
  • Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
  • CNS reactions including nervousness, confusion, sleep disturbances
  • Local phlebitis following intravenous administration

Pregnancy & Lactation

  • Safety in human pregnancy not established
  • Low concentrations excreted in human milk

Precautions & Warnings

  • Risk of anaphylactic shock
  • Potential gallbladder sludge
  • Regular blood checks during prolonged treatment

Use in Special Populations

  • Avoid in neonates if premature or newborn (up to 28 days of age)

Overdose Effects

  • No specific antidote
  • Symptomatic treatment

Therapeutic Class

  • Third generation cephalosporins

Storage Conditions

  • Store in a cool, dry place (below 30°C)
  • Away from light & moisture
  • Keep out of the reach of children

Related Brands