Inoxon 1 gm/vial (IM Injection)

1 gm vial: ৳ 160.00

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Rephco pharmaceuticals ltd
Also available as
Inoxon 250 mg injection Inoxon 500 mg injection Inoxon 250 mg injection Inoxon 500 mg injection Inoxon 1 gm injection Inoxon 2 gm injection

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

  • Potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms
  • Interferes with the synthesis of the bacterial cell wall
  • High stability in the presence of beta lactamases
  • Relatively long plasma elimination half-life of about 6 to 9 hours
  • Not metabolized in the body
  • About 40-65% of a dose excreted unchanged in the urine
  • Highly protein bound (95%)

Dosage

  • Usual adult dose: 1 to 2 gm by intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
  • Maximum adult dose: 4 gm/day
  • Usual infant and children's dose: 50 to 75 mg/kg intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
  • Maximum pediatric dose: 4 gm/day
  • Duration of therapy: 4 to 14 days; in complicated infections, longer therapy may be required

Administration

  • Intramuscular injection solution preparation
  • Intravenous injection solution preparation
  • Injection time and concentration
  • Recommended patient tolerance test
  • Solution stability

Interaction

  • No reported drug interactions

Contraindications

  • Not to be given to patients with a history of hypersensitivity to cephalosporin antibiotics

Side Effects

  • Gastro-intestinal effects including diarrhea, nausea, vomiting, stomatitis, and glossitis
  • Cutaneous reactions including rash, pruritus, urticaria, edema, and erythema multiforme
  • Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia, and neutropenia
  • Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
  • CNS reactions including nervousness, confusion, sleep disturbances, headache, and dizziness
  • Local phlebitis occurs rarely following intravenous administration

Pregnancy & Lactation

  • Safety not established in human pregnancy
  • Low concentrations excreted in human milk
  • Caution advised during lactation

Precautions & Warnings

  • Potential for anaphylactic shock
  • Possibility of gallbladder sludge
  • Blood picture should be checked during prolonged treatment

Use in Special Populations

  • Must not be given to premature and newborn neonates (up to 28 days of age)

Overdose Effects

  • No specific antidote
  • Symptomatic treatment advised

Therapeutic Class

  • Third generation Cephalosporins

Storage Conditions

  • Store in a cool, dry place (below 30°C), away from light & moisture
  • Keep out of the reach of children

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