Inoxon 500 mg/vial (IV Injection)

500 mg vial: ৳ 120.00

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Rephco pharmaceuticals ltd
Also available as
Inoxon 250 mg injection Inoxon 500 mg injection Inoxon 1 gm injection Inoxon 250 mg injection Inoxon 1 gm injection Inoxon 2 gm injection

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

  • Potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms
  • Interferes with the synthesis of the bacterial cell wall
  • High stability in the presence of beta lactamases
  • Relatively long plasma elimination half-life of about 6 to 9 hours
  • Not metabolized in the body
  • Highly protein bound (95%)

Dosage

  • Usual dose for adults is 1 to 2 gm by intravenous or intramuscular administration once a day
  • Maximum adult dose: 4 gm/day
  • Usual dose for infants and children (01 month or older) is 50 to 75 mg/kg intravenous or intramuscular administration once a day
  • Maximum pediatric dose: 2 gm/day
  • Duration of therapy: 4 to 14 days

Administration

  • Preparation of Solutions for Intramuscular / Intravenous Injections using Lidocaine HCI 1% or Water for injection USP
  • Injection should be administered over 2-4 minutes or by tubing infusion over a period of 30 minutes
  • Patient tolerance test required before starting treatment

Interaction

  • No drug interactions reported

Contraindications

  • Not to be given to patients with a history of hypersensitivity to cephalosporin antibiotics

Side Effects

  • Gastro-intestinal effects including diarrhea, nausea and vomiting, stomatitis and glossitis
  • Cutaneous reactions including rash, pruritus, urticaria, edema and erythema multiforme
  • Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia and neutropenia
  • Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
  • CNS reactions including nervousness, confusion, sleep disturbances, headache, hyperactivity, convulsion, hypertonia and dizziness
  • Local phlebitis occurs rarely following intravenous administration

Pregnancy & Lactation

  • Safety in human pregnancy not established
  • Cautious use in lactating mothers

Precautions & Warnings

  • Anaphylactic shock considerations
  • Sonogram findings related to gallbladder
  • Blood picture check during prolonged treatment

Use in Special Populations

  • Must not be given to premature and newborn neonates (up to 28 days of age)

Overdose Effects

  • No specific antidote available
  • Treatment should be symptomatic

Therapeutic Class

  • Third generation Cephalosporins

Storage Conditions

  • Store in a cool, dry place below 30°C, away from light & moisture
  • Keep out of the reach of children

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