Inoxon 2 gm/vial (IV Injection)

2 gm vial: ৳ 300.00

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Rephco pharmaceuticals ltd
Also available as
Inoxon 250 mg injection Inoxon 500 mg injection Inoxon 1 gm injection Inoxon 250 mg injection Inoxon 500 mg injection Inoxon 1 gm injection

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

  • 3rd generation broad-spectrum parenteral cephalosporin antibiotic
  • Bactericidal activity against a wide range of Gram-positive and Gram-negative organisms
  • Interferes with the synthesis of the bacterial cell wall
  • High stability in the presence of beta lactamases
  • Relatively long plasma elimination half-life of 6 to 9 hours
  • Not metabolized in the body
  • Highly protein bound (95%)
  • 40-65% excreted unchanged in urine

Dosage

  • Adult dosage: 1 to 2 gm by intravenous or intramuscular administration once a day
  • Maximum adult dose: 4 gm/day
  • Pediatric dosage: 50 to 75 mg/kg intravenous or intramuscular administration once a day
  • Duration of therapy: 4 to 14 days for usual infections

Administration

  • Preparation of Solutions for Intramuscular / Intravenous Injections
  • Injection administered over 2-4 minutes
  • Patient tolerance test recommended before starting treatment
  • Freshly reconstituted solution is recommended
  • Maintains potency for at least 6 hours at room temperature or 24 hours at 5°C

Interaction

  • No drug interactions reported

Contraindications

  • Hypersensitivity to cephalosporin antibiotics

Side Effects

  • Gastro-intestinal effects including diarrhea, nausea and vomiting
  • Cutaneous reactions including rash, pruritus, urticaria, edema and erythema multiforme
  • Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia and neutropenia
  • Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
  • CNS reactions including nervousness, confusion, sleep disturbances, headache, hyperactivity, convulsion, hypertonia and dizziness
  • Local phlebitis occurs rarely following intravenous administration

Pregnancy & Lactation

  • Safety in human pregnancy not established
  • Caution exercised when administered to a lactating mother

Precautions & Warnings

  • Potential for anaphylactic shock
  • Gallbladder sludge reversible upon discontinuation or completion of therapy
  • Blood picture should be checked at regular intervals during prolonged treatment

Use in Special Populations

  • Not to be given to premature and newborn neonates

Overdose Effects

  • No specific antidote
  • Treatment should be symptomatic

Therapeutic Class

  • Third generation cephalosporins

Storage Conditions

  • Vial store in a cool, dry place below 30°C
  • Away from light & moisture
  • Keep out of the reach of children

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