Keptrix 1 gm/vial (IM Injection)

1 gm vial: ৳ 150.00

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Apex pharmaceuticals ltd
Also available as
Keptrix 500 mg injection Keptrix 1 gm injection Keptrix 2 gm injection

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

  • Broad-spectrum parenteral cephalosporin antibiotic
  • Potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms
  • Interferes with the synthesis of the bacterial cell wall
  • Long plasma elimination half-life of about 6 to 9 hours
  • High degree of stability in the presence of beta lactamases
  • Not metabolized in the body
  • Highly protein bound (95%)

Dosage

  • Usual dose for adults: 1 to 2 gm by intravenous or intramuscular administration once a day
  • Usual dose for infants and children: 50 to 75 mg/kg intravenous or intramuscular administration once a day
  • Maximum dose for adults: 4 gm/day
  • Duration of therapy: 4 to 14 days; longer therapy may be required in complicated infections

Administration

  • Solutions for Intramuscular / Intravenous Injections preparation guidelines
  • Intramuscular Injection: 250 mg or 500 mg Ceftriaxone should be dissolved in Lidocaine HCI 1% injection
  • Intravenous Injection: 250 mg or 500 mg Ceftriaxone should be dissolved in Water for injection
  • Administered over 2-4 minutes by Intramuscular or Intravenous injection or tubing infusion over a period of 30 minutes
  • Patient tolerance test should be checked by administration of a test dose

Interaction

  • No reported drug interactions

Contraindications

  • Not to be given to patients with a history of hypersensitivity to cephalosporin antibiotics

Side Effects

  • Gastro-intestinal effects including diarrhea, nausea, vomiting, stomatitis, and glossitis
  • Cutaneous reactions including rash, pruritus, urticaria, edema, and erythema multiforme
  • Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia, and neutropenia
  • Hepatic reactions including elevations of SGOT or SGPT, and bilirubinemia
  • CNS reactions including nervousness, confusion, sleep disturbances, headache, hyperactivity, convulsion, and dizziness
  • Local phlebitis occurs rarely following intravenous administration

Pregnancy & Lactation

  • Safety in human pregnancy not established
  • Caution should be exercised when administered to a lactating mother

Precautions & Warnings

  • Anaphylactic shock cannot be ruled out
  • Shadows suggesting sludge have been detected by sonograms of the gallbladder in rare cases

Use in Special Populations

  • Not to be given to neonates if premature or newborn (up to 28 days of age)

Overdose Effects

  • No specific antidote
  • Treatment should be symptomatic

Therapeutic Class

  • Third generation Cephalosporins

Storage Conditions

  • Store in a cool, dry place (below 30° C), away from light & moisture

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