Odatrix 500 mg/vial (IM Injection)

500 mg vial: ৳ 120.00

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Unimed unihealth pharmaceuticals ltd
Also available as
Odatrix 1 gm injection Odatrix 2 gm injection

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

Ceftriaxone is a 3rd generation broad-spectrum parenteral cephalosporin antibiotic with potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. It kills bacteria by interfering with the synthesis of the bacterial cell wall. Ceftriaxone has a relatively long plasma elimination half-life of about 6 to 9 hours, and is not metabolized in the body. It is highly protein bound (95%).

Dosage

  • Adult:
    • 1 to 2 gm by intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
    • Maximum dose: 4 gm/day
  • Infants and Children (01 month or older):
    • 50 to 75 mg/kg intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
    • Maximum dose: 2 gm/day
    • Duration of therapy: 4 to 14 days; longer therapy may be required in complicated infections

Administration

  • Intramuscular Injection: 250 mg or 500 mg Ceftriaxone should be dissolved in Lidocaine HCI 1% injection
  • Intravenous Injection: 250 mg or 500 mg Ceftriaxone should be dissolved in Water for injection; 1 g Ceftriaxone in 10 ml of Water for injection USP or 2 g Ceftriaxone in 20 ml of Water for injection
  • Recommended administration over 2-4 minutes for injections, and patient tolerance test before treatment

Interaction

No drug interactions reported

Contraindications

Ceftriaxone should not be given to patients with a history of hypersensitivity to cephalosporin antibiotics

Side Effects

  • Gastrointestinal effects including diarrhea, nausea, vomiting, stomatitis, and glossitis
  • Cutaneous reactions including rash, pruritus, urticaria, edema, and erythema multiforme
  • Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia, and neutropenia
  • Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
  • CNS reactions including nervousness, confusion, sleep disturbances, headache, and dizziness
  • Local phlebitis occurs rarely

Pregnancy & Lactation

Safety in human pregnancy not established; caution advised during lactation

Precautions & Warnings

  • Anaphylactic shock may occur and requires immediate countermeasures
  • Rare cases of gallbladder sludge detected by sonograms
  • Blood picture should be checked regularly during prolonged treatment

Use in Special Populations

Must not be given to neonates if premature and newborn (up to 28 days of age)

Overdose Effects

No specific antidote; treatment should be symptomatic

Therapeutic Class

Third generation Cephalosporins

Storage Conditions

Store in a cool, dry place (below 30° C), away from light & moisture; Keep out of the reach of children

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