Oricef 250 mg/vial (IM Injection)

250 mg vial: ৳ 130.00

Medicine Details

Category	Details
Generic	Ceftriaxone sodium
Company	Healthcare pharmaceuticals ltd
Also available as	Oricef 500 mg injection Oricef 1 gm injection Oricef 250 mg injection Oricef 500 mg injection Oricef 1 gm injection Oricef 2 gm injection

Indications

Lower respiratory tract infections
Acute Bacterial Otitis Media
Skin and skin structure infections
Urinary tract infections
Gonorrhea
Bacterial Septicemia
Bone and joint infections
Meningitis
Prevention of postoperative infections
Perioperative prophylaxis of infections associated with surgery

Pharmacology

Ceftriaxone is a 3rd generation broad-spectrum parenteral cephalosporin antibiotic. It has potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. Ceftriaxone kills bacteria by interfering with the synthesis of the bacterial cell wall. It has a relatively long plasma elimination half-life of about 6 to 9 hours, is not metabolized in the body, and is excreted unchanged in the urine. The drug is highly protein bound (95%).

Dosage

1 to 2 gm by intravenous or intramuscular administration once a day for adults
50 to 75 mg/kg intravenous or intramuscular administration once a day for infants and children

Administration

Intramuscular Injection: 250 mg or 500 mg Ceftriaxone should be dissolved in Lidocaine HCI 1% injection
Intravenous Injection: 250 mg or 500 mg Ceftriaxone should be dissolved in Water for injection

Interaction

No drug interactions have been reported.

Contraindications

Ceftriaxone should not be given to patients with a history of hypersensitivity to cephalosporin antibiotics.

Side Effects

Gastro-intestinal effects including diarrhea, nausea and vomiting
Cutaneous reactions including rash, pruritus, urticaria
Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia
Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
CNS reactions including nervousness, confusion, sleep disturbances, headache

Pregnancy & Lactation

Its safety in human pregnancy has not been established. Caution should be exercised when Ceftriaxone is administered to a lactating mother.

Precautions & Warnings

Anaphylactic shock cannot be ruled out
Shadows suggesting sludge have been detected by sonograms of the gallbladder
Blood picture should be checked at regular intervals during prolonged treatment

Use in Special Populations

Oricef must not be given to neonates if the neonate is premature and newborn (up to 28 days of age).

Overdose Effects

There is no specific antidote. Treatment of overdosage should be symptomatic.

Therapeutic Class

Third generation Cephalosporins

Storage Conditions

Vial store in a cool, dry place (below 30°C), away from light & moisture. Keep out of the reach of children.