Oricef 1 gm/vial (IM Injection)

1 gm vial: ৳ 320.00

Medicine Details

Category	Details
Generic	Ceftriaxone sodium
Company	Healthcare pharmaceuticals ltd
Also available as	Oricef 250 mg injection Oricef 500 mg injection Oricef 250 mg injection Oricef 500 mg injection Oricef 1 gm injection Oricef 2 gm injection

Indications

Lower respiratory tract infections
Acute Bacterial Otitis Media
Skin and skin structure infections
Urinary tract infections
Gonorrhea
Bacterial Septicemia
Bone and joint infections
Meningitis
Prevention of postoperative infections
Perioperative prophylaxis of infections associated with surgery

Pharmacology

Ceftriaxone is a 3rd generation broad-spectrum parenteral cephalosporin antibiotic that kills bacteria by interfering with the synthesis of the bacterial cell wall. It has a long plasma elimination half-life, is not metabolized in the body, and is highly protein bound (95%).

Dosage

Adult:
- Usual dose: 1 to 2 gm by intravenous or intramuscular administration once a day
- Maximum dose: 4 gm/day
Infants and Children (01 month or older):
- Usual dose: 50 to 75 mg/kg intravenous or intramuscular administration once a day
- Maximum dose: 2 gm/day
Duration of therapy: Continue for more than 2 days after signs and symptoms of infection have disappeared. Usual duration is 4 to 14 days; in complicated infections, longer therapy may be required.

Administration

Preparation of Solutions for Intramuscular / Intravenous Injections
Injection should be administered over 2-4 minutes, by Intramuscular or Intravenous injection or by tubing infusion over a period of 30 minutes at concentration between 10 mg/mL and 40 mg/mL
Patient tolerance test should be checked by administration of a test dose

Interaction

No drug interactions have been reported.

Contraindications

Ceftriaxone should not be given to patients with a history of hypersensitivity to cephalosporin antibiotics.

Side Effects

Gastro-intestinal effects including diarrhea, nausea and vomiting, stomatitis and glossitis
Cutaneous reactions including rash, pruritus, urticaria, edema and erythema multiforme
Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia and neutropenia
Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
CNS reactions including nervousness, confusion, sleep disturbances, headache, hyperactivity, convulsion, hypertonia and dizziness
Local phlebitis occurs rarely following intravenous administration but can be minimized by slow injections

Pregnancy & Lactation

Safety in human pregnancy has not been established
Caution should be exercised when Ceftriaxone is administered to a lactating mother

Precautions & Warnings

Anaphylactic shock requires immediate countermeasures such as intravenous epinephrine followed by a glucocorticoid
Shadows suggesting sludge have been detected by sonograms of the gallbladder in rare cases
Blood picture should be checked at regular intervals during prolonged treatment

Use in Special Populations

Oricef must not be given to neonates if the neonate is premature and newborn (up to 28 days of age).

Overdose Effects

There is no specific antidote. Treatment of overdosage should be symptomatic.

Therapeutic Class

Third generation Cephalosporins

Storage Conditions

Vial store in a cool, dry place (below 30° C), away from light & moisture. Keep out of the reach of children.