Oricef 250 mg/vial (IV Injection)

250 mg vial: ৳ 130.00

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Healthcare pharmaceuticals ltd
Also available as
Oricef 250 mg injection Oricef 500 mg injection Oricef 1 gm injection Oricef 500 mg injection Oricef 1 gm injection Oricef 2 gm injection

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

  • Broad-spectrum parenteral cephalosporin antibiotic
  • Potent bactericidal activity
  • Interference with bacterial cell wall synthesis
  • Long plasma elimination half-life
  • High stability in the presence of beta lactamases
  • Non-metabolized

Dosage

  • Usual dose for adults: 1 to 2 gm by intravenous or intramuscular administration once a day
  • Maximum adult dose: 4 gm/day
  • Usual dose for infants and children: 50 to 75 mg/kg intravenous or intramuscular administration once a day
  • Maximum pediatric dose: 2 gm/day
  • Duration of therapy: 4 to 14 days, longer for complicated infections

Administration

  • Preparation of solutions for intramuscular/intravenous injections
  • Intramuscular injection preparation in Lidocaine HCI 1% injection
  • Intravenous injection preparation in Water for injection
  • Administration over 2-4 minutes for intramuscular or intravenous injection
  • Tubing infusion over a period of 30 minutes
  • Patient tolerance test recommended before starting treatment

Interaction

  • No drug interactions reported

Contraindications

  • Hypersensitivity to cephalosporin antibiotics

Side Effects

  • Gastro-intestinal effects including diarrhea, nausea, vomiting, stomatitis, and glossitis
  • Cutaneous reactions including rash, pruritus, urticaria, edema, and erythema multiforme
  • Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia, and neutropenia
  • Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
  • CNS reactions including nervousness, confusion, sleep disturbances, headache, hyperactivity, convulsion, hypertonia, and dizziness
  • Rare occurrence of local phlebitis following intravenous administration

Pregnancy & Lactation

  • Safety in human pregnancy not established
  • Caution in lactating mothers

Precautions & Warnings

  • Risk of anaphylactic shock
  • Possibility of gallbladder conditions
  • Monitoring blood picture during prolonged treatment

Use in Special Populations

  • Avoid in premature and newborn neonates (up to 28 days of age)

Overdose Effects

  • No specific antidote, treatment should be symptomatic

Therapeutic Class

  • Third generation Cephalosporins

Storage Conditions

  • Store below 30°C, away from light and moisture

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