Oricef 500 mg/vial (IV Injection)

500 mg vial: ৳ 200.00

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Healthcare pharmaceuticals ltd
Also available as
Oricef 250 mg injection Oricef 500 mg injection Oricef 1 gm injection Oricef 250 mg injection Oricef 1 gm injection Oricef 2 gm injection

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

Ceftriaxone is a 3rd generation broad-spectrum parenteral cephalosporin antibiotic. It has potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. Like other cephalosporins and penicillins, Ceftriaxone kills bacteria by interfering with the synthesis of the bacterial cell wall. Ceftriaxone has a high degree of stability in the presence of beta lactamases. A remarkable feature of Ceftriaxone is its relatively long plasma elimination half-life of about 6 to 9 hours, which makes single or once-daily dosage of the drug appropriate for most patients. Ceftriaxone is not metabolized in the body. About 40-65% of a dose of Ceftriaxone is excreted unchanged in the urine; the remainder is excreted in the bile and ultimately found in the feces as unchanged drug and microbiologically inactive compound. The drug is highly protein bound (95%).

Dosage

  • Adult:
    • 1 to 2 gm by intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
    • Maximum dose: 4 gm/day
  • Infants and Children (01 month or older):
    • 50 to 75 mg/kg intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
    • Maximum dose: 2 gm/day
  • Duration of therapy: Continue for more than 2 days after signs and symptoms of infection have disappeared. Usual duration is 4 to 14 days; in complicated infections, longer therapy may be required.

Administration

  • Preparation for Intramuscular Injection:
    • 250 mg or 500 mg Ceftriaxone dissolved in Lidocaine HCI 1% injection
    • 1 g Ceftriaxone in 3.5 ml of Lidocaine HCI 1% injection
  • Preparation for Intravenous Injection:
    • 250 mg or 500 mg Ceftriaxone dissolved in Water for injection
    • 1 g Ceftriaxone in 10 ml of Water for injection
    • 2 g Ceftriaxone in 20 ml of Water for injection
  • Injection Time: 2-4 minutes for intramuscular or intravenous injection, 30 minutes for tubing infusion
  • Patient Tolerance Test: Checked by administration of a test dose
  • Reconstituted Solution: Maintains potency for at least 6 hours at room temperature or 24 hours at 5°C

Interaction

No drug interactions have been reported.

Contraindications

Ceftriaxone should not be given to patients with a history of hypersensitivity to cephalosporin antibiotics.

Side Effects

  • Gastro-intestinal effects
  • Cutaneous reactions
  • Hematologic reactions
  • Hepatic reactions
  • CNS reactions
  • Local phlebitis

Pregnancy & Lactation

Safety in human pregnancy has not been established. Caution should be exercised when administered to a lactating mother.

Precautions & Warnings

  • Anaphylactic shock
  • Gallbladder sludge
  • Blood picture checking during prolonged treatment

Use in Special Populations

Must not be given to neonates if premature and newborn (up to 28 days of age)

Overdose Effects

No specific antidote. Treatment should be symptomatic.

Therapeutic Class

Third generation Cephalosporins

Storage Conditions

Store in a cool, dry place (below 30°C), away from light & moisture. Keep out of the reach of children.

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