Oryx 250 mg/vial (IM Injection)

250 mg vial: ৳ 100.00

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Rangs pharmaceuticals ltd
Also available as
Oryx 500 mg injection Oryx 1 gm injection Oryx 250 mg injection Oryx 500 mg injection Oryx 1 gm injection Oryx 2 gm injection

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

  • Broad-spectrum parenteral cephalosporin antibiotic
  • Bactericidal activity against a wide range of Gram-positive and Gram-negative organisms
  • Interferes with the synthesis of the bacterial cell wall
  • High stability in the presence of beta lactamases
  • Long plasma elimination half-life of about 6 to 9 hours
  • Not metabolized in the body
  • Highly protein bound (95%)

Dosage

  • Adult: 1 to 2 gm by intravenous or intramuscular administration once a day
  • Infants and Children (01 month or older): 50 to 75 mg/kg intravenous or intramuscular administration once a day
  • Uncomplicated gonococcal infections: 250 mg IM as a single dose
  • Surgical prophylaxis: 1 g IV as a single dose 30 to 120 minutes before surgery
  • Duration of therapy: Usual duration is 4 to 14 days; longer therapy may be required in complicated infections

Administration

  • Preparation of Solutions for Intramuscular / Intravenous Injections
  • Intramuscular Injection preparation with Lidocaine HCI 1%
  • Intravenous Injection preparation with Water for injection
  • Injection administered over 2-4 minutes

Interaction

No drug interactions reported

Contraindications

Hypersensitivity to cephalosporin antibiotics

Side Effects

  • Gastro-intestinal effects including diarrhea, nausea, vomiting, stomatitis, and glossitis
  • Cutaneous reactions including rash, pruritus, urticaria, edema, and erythema multiforme
  • Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia, and neutropenia
  • Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
  • CNS reactions including nervousness, confusion, sleep disturbances, headache, hyperactivity, convulsion, hypertonia, and dizziness
  • Local phlebitis following intravenous administration

Pregnancy & Lactation

Unsafe in human pregnancy, caution in lactation

Precautions & Warnings

  • Risk of anaphylactic shock
  • Possible gallbladder sludge detected
  • Regular blood picture checks during prolonged treatment

Use in Special Populations

Avoid in premature and newborn neonates

Overdose Effects

No specific antidote, symptomatic treatment

Therapeutic Class

Third generation Cephalosporins

Storage Conditions

Store in a cool, dry place (below 30°C), away from light and moisture

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