Oryx 500 mg/vial (IM Injection)

500 mg vial: ৳ 150.00

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Rangs pharmaceuticals ltd
Also available as
Oryx 250 mg injection Oryx 1 gm injection Oryx 250 mg injection Oryx 500 mg injection Oryx 1 gm injection Oryx 2 gm injection

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

Ceftriaxone is a 3rd generation broad-spectrum parenteral cephalosporin antibiotic with potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. It interferes with the synthesis of the bacterial cell wall and has a high degree of stability in the presence of beta lactamases. Ceftriaxone has a long plasma elimination half-life, is not metabolized in the body, and is highly protein bound.

Dosage

  • Usual dose for adults: 1 to 2 gm by intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
  • Maximum dose for adults: 4 gm/day
  • Usual dose for infants and children: 50 to 75 mg/kg intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
  • Maximum dose for infants and children: 2 gm/day
  • Duration of therapy: Continue for more than 2 days after signs and symptoms of infection have disappeared. Usual duration is 4 to 14 days; in complicated infections, longer therapy may be required

Administration

  • Preparation of Solutions for Intramuscular / Intravenous Injections
  • Intramuscular Injection: 250 mg or 500 mg Ceftriaxone should be dissolved in Lidocaine HCI 1%
  • Intravenous Injection: 250 mg or 500 mg Ceftriaxone should be dissolved in Water for injection

Interaction

No drug interactions have been reported.

Contraindications

Ceftriaxone should not be given to patients with a history of hypersensitivity to cephalosporin antibiotics.

Side Effects

  • Gastro-intestinal effects including diarrhea, nausea and vomiting, stomatitis and glossitis
  • Cutaneous reactions including rash, pruritus, urticaria, edema and erythema multiforme
  • Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia and neutropenia
  • Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
  • CNS reactions including nervousness, confusion, sleep disturbances, headache, hyperactivity, convulsion, hypertonia and dizziness
  • Local phlebitis following intravenous administration

Pregnancy & Lactation

Its safety in human pregnancy has not been established. Caution should be exercised when Ceftriaxone is administered to a lactating mother.

Precautions & Warnings

  • Anaphylactic shock
  • Shadows suggesting sludge in the gallbladder
  • Blood picture should be checked at regular intervals during prolonged treatment

Use in Special Populations

Oryx must not be given to neonates if the neonate is premature and newborn (up to 28 days of age).

Overdose Effects

There is no specific antidote. Treatment of overdosage should be symptomatic.

Therapeutic Class

Third generation Cephalosporins

Storage Conditions

Vial store in a cool, dry place (below 30° C), away from light & moisture. Keep out of the reach of children.

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