Oryx 1 gm/vial (IM Injection)

1 gm vial: ৳ 200.00

Medicine Details

Category	Details
Generic	Ceftriaxone sodium
Company	Rangs pharmaceuticals ltd
Also available as	Oryx 250 mg injection Oryx 500 mg injection Oryx 250 mg injection Oryx 500 mg injection Oryx 1 gm injection Oryx 2 gm injection

Indications

Lower respiratory tract infections
Acute Bacterial Otitis Media
Skin and skin structure infections
Urinary tract infections
Gonorrhea
Bacterial Septicemia
Bone and joint infections
Meningitis
Prevention of postoperative infections
Perioperative prophylaxis of infections associated with surgery

Pharmacology

Ceftriaxone is a 3rd generation broad-spectrum parenteral cephalosporin antibiotic with potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. It kills bacteria by interfering with the synthesis of the bacterial cell wall. Ceftriaxone has a long plasma elimination half-life of about 6 to 9 hours, which allows for once-daily dosage. It is not metabolized in the body and is highly protein bound (95%).

Dosage

Adult:
- 1 to 2 gm by intravenous or intramuscular administration once a day
- 1 to 2 g IV or IM once a day (or in equally divided doses twice a day) for various infections
- Max dose: 4 gm/day
Infants and Children (01 month or older):
- 50 to 75 mg/kg intravenously or intramuscularly once a day
- Duration: 4 to 14 days; longer in complicated infections

Administration

Preparation of Solutions for Intramuscular / Intravenous Injections
For Intramuscular Injection: 250 mg or 500 mg Ceftriaxone should be dissolved in Lidocaine HCI 1% injection
For Intravenous Injection: 250 mg or 500 mg Ceftriaxone should be dissolved in Water for injection

Interaction

No drug interactions reported

Contraindications

Not to be given to patients with a history of hypersensitivity to cephalosporin antibiotics

Side Effects

Gastro-intestinal effects including diarrhea, nausea, and vomiting
Cutaneous reactions including rash, urticaria, and edema
Hematologic reactions including eosinophilia and thrombocytopenia
Hepatic reactions including elevations of SGOT or SGPT
CNS reactions including nervousness, confusion, and headache
Local phlebitis occurs rarely following intravenous administration

Pregnancy & Lactation

Safety in human pregnancy not established; caution in lactating mother

Precautions & Warnings

Anaphylactic shock may occur
Gallbladder sludge detected in rare cases
Regular blood picture checks during prolonged treatment

Use in Special Populations

Must not be given to premature and newborn neonates (up to 28 days of age)

Overdose Effects

No specific antidote; treatment should be symptomatic

Therapeutic Class

Third generation Cephalosporins

Storage Conditions

Store vial in a cool, dry place (below 30° C), away from light & moisture; Keep out of the reach of children