Oryx 500 mg/vial (IV Injection)

500 mg vial: ৳ 150.00

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Rangs pharmaceuticals ltd
Also available as
Oryx 250 mg injection Oryx 500 mg injection Oryx 1 gm injection Oryx 250 mg injection Oryx 1 gm injection Oryx 2 gm injection

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

Ceftriaxone is a 3rd generation broad-spectrum parenteral cephalosporin antibiotic with potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. It kills bacteria by interfering with the synthesis of the bacterial cell wall. Ceftriaxone has a high degree of stability in the presence of beta lactamases and a relatively long plasma elimination half-life of about 6 to 9 hours. It is not metabolized in the body and is highly protein bound (95%).

Dosage

  • 1 to 2 gm by intravenous or intramuscular administration once a day (or in equally divided doses twice a day) for adults
  • 50 to 75 mg/kg intravenous or intramuscular administration once a day (or in equally divided doses twice a day) for infants and children (01 month or older)

Administration

  • Intramuscular Injection: 250 mg or 500 mg Ceftriaxone dissolved in Lidocaine HCI 1% injection
  • Intravenous Injection: 250 mg or 500 mg Ceftriaxone dissolved in Water for Injection USP

Interaction

No drug interactions reported.

Contraindications

Not for patients with a history of hypersensitivity to cephalosporin antibiotics.

Side Effects

  • Gastro-intestinal effects including diarrhea, nausea and vomiting
  • Cutaneous reactions including rash, pruritus, urticaria
  • Hematologic reactions including eosinophilia, thrombocytopenia
  • Hepatic reactions including elevations of SGOT or SGPT
  • CNS reactions including nervousness, confusion, sleep disturbances

Pregnancy & Lactation

Not established for safety in human pregnancy. Caution advised during lactation.

Precautions & Warnings

  • Anaphylactic shock cannot be ruled out
  • Shadows suggesting sludge have been detected by sonograms of the gallbladder
  • Blood picture should be checked during prolonged treatment

Use in Special Populations

Not for premature and newborn neonates (up to 28 days of age)

Overdose Effects

No specific antidote. Treatment should be symptomatic.

Therapeutic Class

Third generation Cephalosporins

Storage Conditions

Vial should be stored in a cool, dry place (below 30° C), away from light and moisture. Keep out of the reach of children.

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