Oryx 1 gm/vial (IV Injection)
1 gm vial: ৳ 200.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Ceftriaxone sodium |
| Company | Rangs pharmaceuticals ltd |
| Also available as |
Indications
- Lower respiratory tract infections
- Acute Bacterial Otitis Media
- Skin and skin structure infections
- Urinary tract infections
- Gonorrhea
- Bacterial Septicemia
- Bone and joint infections
- Meningitis
- Prevention of postoperative infections
- Perioperative prophylaxis of infections associated with surgery
Pharmacology
- Broad-spectrum parenteral cephalosporin antibiotic
- Potent bactericidal activity against Gram-positive and Gram-negative organisms
- Interferes with bacterial cell wall synthesis
- High degree of stability in the presence of beta lactamases
- Relatively long plasma elimination half-life of 6 to 9 hours
- Not metabolized in the body
- Highly protein bound (95%)
Dosage
- Usual adult dose of 1 to 2 gm by intravenous or intramuscular administration
- Dosing instructions for specific infections like pneumonia, bronchitis, otitis media, skin infections, urinary tract infections, septicemia, and meningitis
- Special dosage instructions for uncomplicated gonococcal infections and surgical prophylaxis
- Usual infant and child dose of 50 to 75 mg/kg intravenous or intramuscular administration
Administration
- Preparation of solutions for intramuscular and intravenous injections
- Recommended dilution instructions for intramuscular and intravenous injections
- Guidelines for administration over a specified period and concentration range
- Recommendation for patient tolerance test before treatment
- Stability information of reconstituted solution
Interaction
- No reported drug interactions
Contraindications
- Historical hypersensitivity to cephalosporin antibiotics
Side Effects
- Gastro-intestinal effects like diarrhea, nausea, and vomiting
- Cutaneous reactions including rash, pruritus, and urticaria
- Hematologic reactions such as eosinophilia, thrombocytopenia, and leucopenia
- Hepatic reactions including elevated liver enzymes
- CNS reactions like nervousness, confusion, and headache
- Local phlebitis following intravenous administration
Pregnancy & Lactation
- Safety not established in human pregnancy
- Caution advised when administered to lactating mothers
Precautions & Warnings
- Potential for anaphylactic shock
- Detection of gallbladder shadows in rare cases
- Recommendation for regular blood picture checks during prolonged treatment
Use in Special Populations
- Avoid use in premature and newborn neonates (up to 28 days of age)
Overdose Effects
- No specific antidote
- Treatment should be symptomatic
Therapeutic Class
- Third generation Cephalosporins
Storage Conditions
- Recommended storage in a cool, dry place below 30°C, away from light and moisture
- Keep out of the reach of children