Parcef 1 gm/vial (IV Injection)

1 gm vial: ৳ 175.00

Medicine Details

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

  • Broad-spectrum parenteral cephalosporin antibiotic
  • Potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms
  • Interferes with the synthesis of the bacterial cell wall
  • High stability in the presence of beta lactamases
  • Relatively long plasma elimination half-life of about 6 to 9 hours
  • Not metabolized in the body

Dosage

  • Usual dose for adults: 1 to 2 gm by intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
  • Maximum dose for adults: 4 gm/day
  • Usual dose for infants and children (01 month or older): 50 to 75 mg/kg intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
  • Maximum dose for infants and children: 2 gm/day

Administration

  • Intramuscular injection preparation
  • Intravenous injection preparation
  • Patient tolerance test by administration of a test dose
  • Freshly reconstituted solution recommended
  • Injection should be administered over 2-4 minutes (for both intramuscular and intravenous injection)

Interaction

  • No reported drug interactions

Contraindications

  • Hypersensitivity to cephalosporin antibiotics

Side Effects

  • Gastro-intestinal effects including diarrhea, nausea and vomiting, stomatitis and glossitis
  • Cutaneous reactions including rash, pruritus, urticaria, edema, and erythema multiforme
  • Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia, and neutropenia
  • Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
  • CNS reactions including nervousness, confusion, sleep disturbances, headache, hyperactivity, convulsion, hypertonia, and dizziness
  • Local phlebitis

Pregnancy & Lactation

  • Safety in human pregnancy not established
  • Caution should be exercised when administered to a lactating mother

Precautions & Warnings

  • Anaphylactic shock possibility
  • Shadows suggesting sludge have been detected by sonograms of the gallbladder
  • Blood picture should be checked at regular intervals during prolonged treatment

Use in Special Populations

  • Must not be given to neonates if premature and newborn (up to 28 days of age)

Overdose Effects

  • No specific antidote
  • Treatment should be symptomatic

Therapeutic Class

  • Third generation Cephalosporins

Storage Conditions

  • Vial store in a cool, dry place (below 30°C)
  • Away from light & moisture
  • Keep out of the reach of children

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