Perix 1 gm/vial (IV Injection)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ceftriaxone sodium |
| Company | Monicopharma ltd |
| Also available as |
Indications
- Lower respiratory tract infections
- Acute Bacterial Otitis Media
- Skin and skin structure infections
- Urinary tract infections
- Gonorrhea
- Bacterial Septicemia
- Bone and joint infections
- Meningitis
- Prevention of postoperative infections
- Perioperative prophylaxis of infections associated with surgery
Pharmacology
Ceftriaxone is a 3rd generation broad-spectrum parenteral cephalosporin antibiotic with potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. It kills bacteria by interfering with the synthesis of the bacterial cell wall. It has a long plasma elimination half-life of about 6 to 9 hours, and is not metabolized in the body. It is highly protein bound (95%).
Dosage
- Adult: 1 to 2 gm by intravenous or intramuscular administration once a day
- Infants and Children (01 month or older): 50 to 75 mg/kg intravenous or intramuscular administration once a day
- Duration of therapy: 4 to 14 days; in complicated infections, longer therapy may be required
Administration
- For Intramuscular Injection: preparation of solution using Lidocaine HCI 1% injection
- For Intravenous Injection: preparation of solution using Water for injection
Interaction
No drug interactions reported
Contraindications
Not for patients with a history of hypersensitivity to cephalosporin antibiotics
Side Effects
- Gastro-intestinal effects including diarrhea, nausea and vomiting
- Cutaneous reactions including rash, pruritus, urticaria
- Hematologic reactions including eosinophilia, thrombocytopenia
- Hepatic reactions including elevations of SGOT or SGPT
- CNS reactions including nervousness, confusion, sleep disturbances
Pregnancy & Lactation
Safety in human pregnancy not established; caution during lactation
Precautions & Warnings
- Anaphylactic shock
- Sonograms of the gallbladder
- Regular blood picture checks during prolonged treatment
Use in Special Populations
Must not be given to neonates if premature and newborn (up to 28 days of age)
Overdose Effects
Symptomatic treatment in case of overdosage
Therapeutic Class
Third generation Cephalosporins
Storage Conditions
Store in a cool, dry place (below 30° C), away from light & moisture