Powercef 2 gm/vial (IV Injection)

2 gm vial: ৳ 300.00

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Chemist laboratories ltd
Also available as
Powercef 250 mg injection Powercef 500 mg injection Powercef 1 gm injection Powercef 1 gm injection

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

Ceftriaxone is a 3rd generation broad-spectrum parenteral cephalosporin antibiotic. It has potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. Ceftriaxone kills bacteria by interfering with the synthesis of the bacterial cell wall. Ceftriaxone has a long plasma elimination half-life of about 6 to 9 hours. It is not metabolized in the body and is highly protein-bound (95%).

Dosage

  • Adult:
    • 1 to 2 gm by intravenous or intramuscular administration once a day
    • 1 to 2 g IV or IM once a day for various infections
    • 250 mg IM as a single dose for uncomplicated gonococcal infections
    • 1 g IV as a single dose 30 to 120 minutes before surgery for surgical prophylaxis
  • Infants and Children:
    • 50 to 75 mg/kg intravenous or intramuscular administration once a day
    • 50 mg/kg IM in single dose for acute bacterial otitis media
    • 100 mg/kg IV or IM in single daily dose for meningitis
  • Duration of therapy: Continue for more than 2 days after signs and symptoms of infection have disappeared. Usual duration is 4 to 14 days; in complicated infections, longer therapy may be required.

Administration

  • Preparation of Solutions for Intramuscular / Intravenous Injections
  • Administered over 2-4 minutes by Intramuscular or Intravenous injection or by tubing infusion over a period of 30 minutes
  • Patient tolerance test recommended before starting treatment through Ceftriaxone injection

Interaction

No drug interactions reported

Contraindications

Ceftriaxone should not be given to patients with a history of hypersensitivity to cephalosporin antibiotics.

Side Effects

  • Gastro-intestinal effects including diarrhea, nausea and vomiting, stomatitis and glossitis
  • Cutaneous reactions including rash, pruritus, urticaria, edema and erythema multiforme
  • Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia and neutropenia
  • Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
  • CNS reactions including nervousness, confusion, sleep disturbances, headache, hyperactivity, convulsion, hypertonia and dizziness
  • Local phlebitis occurs rarely following intravenous administration

Pregnancy & Lactation

Not established for safety in human pregnancy. Caution should be exercised when administered to a lactating mother.

Precautions & Warnings

  • Anaphylactic shock may occur
  • Shadows suggesting sludge have been detected by sonograms of the gallbladder in rare cases
  • Blood picture should be checked at regular intervals during prolonged treatment

Use in Special Populations

Must not be given to neonates if the neonate is premature and newborn (up to 28 days of age).

Overdose Effects

No specific antidote. Treatment should be symptomatic.

Therapeutic Class

Third generation Cephalosporins

Storage Conditions

Vial store in a cool, dry place (below 30° C), away from light & moisture. Keep out of the reach of children.

Related Brands