Rit 500 mg/vial (IM Injection)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ceftriaxone sodium |
| Company | Kemiko pharmaceuticals ltd |
| Also available as |
Indications
- Lower respiratory tract infections
- Acute Bacterial Otitis Media
- Skin and skin structure infections
- Urinary tract infections
- Gonorrhea
- Bacterial Septicemia
- Bone and joint infections
- Meningitis
- Prevention of postoperative infections
- Perioperative prophylaxis of infections associated with surgery
Pharmacology
Ceftriaxone is a 3rd generation broad-spectrum parenteral cephalosporin antibiotic. It has potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. Ceftriaxone kills bacteria by interfering with the synthesis of the bacterial cell wall. It has a high degree of stability in the presence of beta lactamases. Ceftriaxone is not metabolized in the body and is highly protein bound (95%).
Dosage
- Adult:
- 1 to 2 gm by intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
- Maximum dose: 4 gm/day
- Infants and Children (01 month or older):
- 50 to 75 mg/kg intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
- Maximum dose: 2 gm/day
- Duration of therapy: 4 to 14 days; in complicated infections, longer therapy may be required
Administration
- Intramuscular Injection: 250 mg or 500 mg Ceftriaxone should be dissolved in Lidocaine HCI 1% injection
- Intravenous Injection:
- 250 mg or 500 mg Ceftriaxone should be dissolved in Water for injection
- 1 g Ceftriaxone in 10 ml of Water for injection USP or 2 g Ceftriaxone in 20 ml of Water for injection
- Injection Time: 2-4 minutes for intramuscular or intravenous injection; 30 minutes for tubing infusion
- Solution Freshness: Maintains potency for at least 6 hours at room temperature or 24 hours at 5°C
Interaction
No drug interactions have been reported
Contraindications
Ceftriaxone should not be given to patients with a history of hypersensitivity to cephalosporin antibiotics
Side Effects
- Diarrhea
- Nausea and vomiting
- Stomatitis and glossitis
- Rash, pruritus, urticaria, edema and erythema multiforme
- Eosinophilia, thrombocytopenia, leucopenia, anemia and neutropenia
- Elevations of SGOT or SGPT, bilirubinemia
- CNS reactions including nervousness, confusion, sleep disturbances, headache, hyperactivity, convulsion, hypertonia and dizziness
- Local phlebitis following intravenous administration (rare)
Pregnancy & Lactation
Safety in human pregnancy has not been established. Low concentrations are excreted in human milk
Precautions & Warnings
- Risk of anaphylactic shock
- Sonograms may detect shadows in the gallbladder
- Blood picture should be checked during prolonged treatment
Use in Special Populations
Rit must not be given to neonates if premature and newborn (up to 28 days of age)
Overdose Effects
No specific antidote. Treatment should be symptomatic
Therapeutic Class
Third generation Cephalosporins
Storage Conditions
Vial store in a cool, dry place (below 30°C), away from light and moisture. Keep out of the reach of children