Rit 2 gm/vial (IV Injection)
2 gm vial: ৳ 300.90
Medicine Details
| Category | Details |
|---|---|
| Generic | Ceftriaxone sodium |
| Company | Kemiko pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of lower respiratory tract infections
- Treatment of acute bacterial otitis media
- Treatment of skin and skin structure infections
- Treatment of urinary tract infections
- Treatment of gonorrhea
- Treatment of bacterial septicemia
- Treatment of bone and joint infections
- Treatment of meningitis
- Prevention of postoperative infections
- Perioperative prophylaxis of infections associated with surgery
Pharmacology
- 3rd generation broad-spectrum parenteral cephalosporin antibiotic
- Potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms
- Kills bacteria by interfering with the synthesis of the bacterial cell wall
- Relatively long plasma elimination half-life of about 6 to 9 hours
- High degree of stability in the presence of beta lactamases
- Not metabolized in the body
- 40-65% of a dose excreted unchanged in the urine
- Highly protein bound (95%)
Dosage
- Usual adult dose: 1 to 2 gm by intravenous or intramuscular administration once a day
- Maximum adult dose: 4 gm/day
- Usual pediatric dose: 50 to 75 mg/kg intravenous or intramuscular administration once a day
- Maximum pediatric dose: 2 gm/day
- Duration of therapy: 4 to 14 days, longer in complicated infections
Administration
- Preparation of solutions for intramuscular or intravenous injections
- Injection should be administered over 2-4 minutes
- Freshly reconstituted solution recommended
- Maintains potency for at least 6 hours at room temperature or 24 hours at 5°C
- Patient tolerance test should be checked by administration of a test dose
Interaction
- No reported drug interactions
Contraindications
- Should not be given to patients with a history of hypersensitivity to cephalosporin antibiotics
Side Effects
- Gastro-intestinal effects including diarrhea, nausea, vomiting, stomatitis, and glossitis
- Cutaneous reactions including rash, pruritus, urticaria, edema, and erythema multiforme
- Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia, and neutropenia
- Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
- CNS reactions including nervousness, confusion, sleep disturbances, headache, hyperactivity, convulsion, hypertonia, and dizziness
- Rare occurrence of local phlebitis following intravenous administration
Pregnancy & Lactation
- Safety in human pregnancy not established
- Caution advised when administered to lactating mothers
Precautions & Warnings
- Anaphylactic shock cannot be ruled out
- Shadows suggesting sludge may be detected by sonograms of the gallbladder
- Blood picture should be checked at regular intervals during prolonged treatment
Use in Special Populations
- Must not be given to neonates if premature and newborn (up to 28 days of age)
Overdose Effects
- No specific antidote
- Treatment should be symptomatic
Therapeutic Class
- Third generation Cephalosporins
Storage Conditions
- Store in a cool, dry place (below 30°C)
- Keep away from light and moisture
- Keep out of the reach of children