Rofecin 1 gm/vial (IM Injection)

1 gm vial: ৳ 361.08

Medicine Details

Category	Details
Generic	Ceftriaxone sodium
Company	Radiant pharmaceuticals ltd
Also available as	Rofecin 500 mg injection Rofecin 500 mg injection Rofecin 1 gm injection Rofecin 2 gm injection

Indications

Lower respiratory tract infections
Acute Bacterial Otitis Media
Skin and skin structure infections
Urinary tract infections
Gonorrhea
Bacterial Septicemia
Bone and joint infections
Meningitis
Prevention of postoperative infections
Perioperative prophylaxis of infections associated with surgery

Pharmacology

Broad-spectrum parenteral cephalosporin antibiotic with potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. Kills bacteria by interfering with the synthesis of the bacterial cell wall. Stable in the presence of beta lactamases. Long plasma elimination half-life of about 6 to 9 hours. Not metabolized in the body. Highly protein bound (95%).

Dosage

Adult: 1 to 2 gm by intravenous or intramuscular administration once a day or in equally divided doses twice a day. Maximum dose: 4 gm/day
Infants and Children (01 month or older): 50 to 75 mg/kg intravenous or intramuscular administration once a day or in equally divided doses twice a day. Maximum dose: 2 gm/day
Duration of therapy: Continue for more than 2 days after signs and symptoms of infection have disappeared. Usual duration is 4 to 14 days; in complicated infections, longer therapy may be required.

Administration

For Intramuscular Injection: Dissolve 250 mg or 500 mg Ceftriaxone in Lidocaine HCI 1% injection or 1 g Ceftriaxone in 3.5 ml of Lidocaine HCI 1% injection
For Intravenous Injection: Dissolve 250 mg or 500 mg Ceftriaxone in Water for injection or 1 g Ceftriaxone in 10 ml of Water for injection USP or 2 g Ceftriaxone in 20 ml of Water for injection. Administer over 2-4 minutes or by tubing infusion over a period of 30 minutes at concentration between 10 mg/mL and 40 mg/mL.

Interaction

No drug interactions reported.

Contraindications

Should not be given to patients with a history of hypersensitivity to cephalosporin antibiotics.

Side Effects

Gastro-intestinal effects including diarrhea, nausea and vomiting, stomatitis and glossitis
Cutaneous reactions including rash, pruritus, urticaria, edema and erythema multiforme
Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia and neutropenia
Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
CNS reactions including nervousness, confusion, sleep disturbances, headache, hyperactivity, convulsion, hypertonia and dizziness
Local phlebitis following intravenous administration

Pregnancy & Lactation

Safety in human pregnancy not established. Caution should be exercised when administered to a lactating mother.

Precautions & Warnings

Anaphylactic shock risk
Shadows suggesting sludge have been detected by sonograms of the gallbladder
Blood picture check during prolonged treatment

Use in Special Populations

Not to be given to premature and newborn neonates (up to 28 days of age).

Overdose Effects

No specific antidote. Treatment should be symptomatic.

Therapeutic Class

Third generation Cephalosporins

Storage Conditions

Vial store in a cool, dry place (below 30°C), away from light & moisture. Keep out of the reach of children.