Rofecin 500 mg/vial (IV Injection)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ceftriaxone sodium |
| Company | Radiant pharmaceuticals ltd |
| Also available as |
Indications
- Lower respiratory tract infections
- Acute Bacterial Otitis Media
- Skin and skin structure infections
- Urinary tract infections
- Gonorrhea
- Bacterial Septicemia
- Bone and joint infections
- Meningitis
- Prevention of postoperative infections
- Perioperative prophylaxis of infections associated with surgery
Pharmacology
Ceftriaxone is a 3rd generation broad-spectrum parenteral cephalosporin antibiotic with potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. It interferes with the synthesis of the bacterial cell wall and has a long plasma elimination half-life of 6 to 9 hours.
Dosage
- Adult:
- 1 to 2 gm by intravenous or intramuscular administration once a day
- Maximum dose: 4 gm/day
- Infants and Children (01 month or older):
- 50 to 75 mg/kg intravenous or intramuscular administration once a day
- Maximum dose: 2 gm/day
- Duration of therapy: 4 to 14 days; in complicated infections, longer therapy may be required.
Administration
- Preparation of Solutions for Intramuscular / Intravenous Injections:
- For Intramuscular Injection: 250 mg or 500 mg Ceftriaxone should be dissolved in Lidocaine HCI 1% injection
- For Intravenous Injection: 250 mg or 500 mg Ceftriaxone should be dissolved in Water for injection USP
Interaction
No drug interactions have been reported.
Contraindications
Patients with a history of hypersensitivity to cephalosporin antibiotics.
Side Effects
- Gastro-intestinal effects including diarrhea, nausea and vomiting
- Cutaneous reactions including rash, pruritus, urticaria
- Hematologic reactions including eosinophilia, thrombocytopenia
- Hepatic reactions including elevations of SGOT or SGPT
- CNS reactions including nervousness, confusion, headache
Pregnancy & Lactation
Not established in human pregnancy. Caution should be exercised when administered to a lactating mother.
Precautions & Warnings
- Anaphylactic shock
- Shadows suggesting sludge in the gallbladder
- Blood picture should be checked at regular intervals during prolonged treatment
Use in Special Populations
Avoid in premature and newborn neonates (up to 28 days of age).
Overdose Effects
No specific antidote. Treatment should be symptomatic.
Therapeutic Class
Third generation Cephalosporins
Storage Conditions
Vial store in a cool, dry place (below 30°C), away from light & moisture. Keep out of the reach of children.