Topcef 250 mg/vial (IM Injection)

250 mg vial: ৳ 90.00

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Navana pharmaceuticals ltd
Also available as
Topcef 500 mg injection Topcef 1 gm injection Topcef 500 mg injection Topcef 1 gm injection Topcef 2 gm injection

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

  • Bactericidal activity against a wide range of Gram-positive and Gram-negative organisms
  • Interferes with the synthesis of bacterial cell wall
  • High stability in the presence of beta lactamases
  • Relatively long plasma elimination half-life of about 6 to 9 hours
  • Not metabolized in the body
  • Highly protein bound (95%)

Dosage

  • Usual adult dose: 1 to 2 gm by intravenous or intramuscular administration once a day
  • Maximum dose for adults: 4 gm/day
  • Usual infant and children dose: 50 to 75 mg/kg intravenous or intramuscular administration once a day
  • Maximum dose for infants and children: 2 gm/day
  • Duration of therapy: 4 to 14 days

Administration

  • Preparation of Solutions for Intramuscular / Intravenous Injections
  • Intramuscular injection: Ceftriaxone should be dissolved in Lidocaine HCI 1% injection
  • Intravenous injection: Ceftriaxone should be dissolved in Water for injection

Interaction

  • No drug interactions reported

Contraindications

  • Not for patients with history of hypersensitivity to cephalosporin antibiotics

Side Effects

  • Gastro-intestinal effects
  • Cutaneous reactions
  • Hematologic reactions
  • Hepatic reactions
  • CNS reactions
  • Local phlebitis

Pregnancy & Lactation

  • Safety in human pregnancy not established
  • Caution in lactating mothers

Precautions & Warnings

  • Risk of anaphylactic shock
  • Possible gallbladder conditions
  • Regular blood picture checks during prolonged treatment

Use in Special Populations

  • Not for neonates if premature and newborn (up to 28 days of age)

Overdose Effects

  • No specific antidote
  • Symptomatic treatment

Therapeutic Class

  • Third generation Cephalosporins

Storage Conditions

  • Store in a cool, dry place (below 30°C)
  • Away from light & moisture

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