Topcef 1 gm/vial (IV Injection)
1 gm vial: ৳ 190.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Ceftriaxone sodium |
| Company | Navana pharmaceuticals ltd |
| Also available as |
Indications
- Lower respiratory tract infections
- Acute Bacterial Otitis Media
- Skin and skin structure infections
- Urinary tract infections
- Gonorrhea
- Bacterial Septicemia
- Bone and joint infections
- Meningitis
- Prevention of postoperative infections
- Perioperative prophylaxis of infections associated with surgery
Pharmacology
- Broad-spectrum activity against Gram-positive and Gram-negative organisms
- Bactericidal activity
- Interferes with bacterial cell wall synthesis
- High stability in the presence of beta lactamases
- Long plasma elimination half-life of 6 to 9 hours
- Not metabolized in the body
- Excretion via urine and feces
- Highly protein bound (95%)
Dosage
- Usual adult dose: 1 to 2 gm by intravenous or intramuscular administration once a day
- Maximum adult dose: 4 gm/day
- Usual pediatric dose: 50 to 75 mg/kg intravenous or intramuscular administration once a day
- Maximum pediatric dose: 2 gm/day
- Duration of therapy: 4 to 14 days
Administration
- Preparation for Intramuscular / Intravenous Injections
- Administered over 2-4 minutes for intramuscular or intravenous injection
- Administered over 30 minutes for tubing infusion
- Patient tolerance test recommended
- Freshly reconstituted solution recommended
Interaction
- No drug interactions reported
Contraindications
- Hypersensitivity to cephalosporin antibiotics
Side Effects
- Gastro-intestinal effects
- Cutaneous reactions
- Hematologic reactions
- Hepatic reactions
- CNS reactions
- Local phlebitis (rare)
Pregnancy & Lactation
- Not established for safety in human pregnancy
- Caution advised during lactation
Precautions & Warnings
- Potential for anaphylactic shock
- Monitoring of blood picture during prolonged treatment
- Caution in neonates, premature and newborns
Use in Special Populations
- Not for premature and newborn neonates up to 28 days of age
Overdose Effects
- No specific antidote. Symptomatic treatment recommended
Therapeutic Class
- Third generation Cephalosporins
Storage Conditions
- Store below 30°C, away from light and moisture