Trax 500 mg/vial (IV Injection)

500 mg vial: ৳ 120.00

Medicine Details

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

  • Broad-spectrum parenteral cephalosporin antibiotic
  • Bactericidal activity against a wide range of Gram-positive and Gram-negative organisms
  • Interferes with the synthesis of the bacterial cell wall
  • High stability in the presence of beta lactamases
  • Relatively long plasma elimination half-life of about 6 to 9 hours
  • Not metabolized in the body
  • Highly protein bound (95%)

Dosage

  • Adult dosage: 1 to 2 gm by intravenous or intramuscular administration once a day
  • Maximum adult dose: 4 gm/day
  • Uncomplicated gonococcal infections dosage: 250 mg IM as a single dose
  • Surgical prophylaxis dosage: 1 g IV as a single dose 30 to 120 minutes before surgery
  • Infant and Children dosage: 50 to 75 mg/kg intravenous or intramuscular administration once a day
  • Maximum pediatric dose: 2 gm/day
  • Duration of therapy: 4 to 14 days

Administration

  • Preparation of solutions for intramuscular and intravenous injections
  • Administered over 2-4 minutes by intramuscular or intravenous injection or by tubing infusion over a period of 30 minutes
  • Patient tolerance test recommended before starting treatment
  • Solution potency maintained for at least 6 hours at room temperature or 24 hours at 5°C

Interaction

  • No drug interactions reported

Contraindications

  • Hypersensitivity to cephalosporin antibiotics

Side Effects

  • Gastro-intestinal effects including diarrhea, nausea, vomiting, stomatitis, and glossitis
  • Cutaneous reactions including rash, pruritus, urticaria, edema, and erythema multiforme
  • Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia, and neutropenia
  • Hepatic reactions including elevations of SGOT or SGPT, and bilirubinemia
  • CNS reactions including nervousness, confusion, sleep disturbances, headache, hyperactivity, convulsion, hypertonia, and dizziness
  • Local phlebitis occurs rarely following intravenous administration

Pregnancy & Lactation

  • Not established for safety in human pregnancy
  • Low concentrations excreted in human milk
  • Caution advised during lactation

Precautions & Warnings

  • Anaphylactic shock may occur
  • Occasional detection of shadows suggesting sludge in the gallbladder
  • Blood picture to be checked during prolonged treatment

Use in Special Populations

  • Not recommended for neonates if premature or up to 28 days of age

Overdose Effects

  • No specific antidote
  • Symptomatic treatment recommended

Therapeutic Class

  • Third generation Cephalosporins

Storage Conditions

  • Store in a cool, dry place below 30°C, away from light and moisture

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