Betacal 5 mg+50 mg (Tablet)
Unit Price: ৳ 6.02 (5 x 10: ৳ 301.00)
Strip Price: ৳ 60.20
Medicine Details
| Category | Details |
|---|---|
| Generic | Amlodipine besilate atenolol |
| Company | Orion pharma ltd |
Indications
- Essential hypertension
- Angina pectoris & hypertension
- Post myocardial infarction
- Refractory angina pectoris
Pharmacology
- Fixed-dose combination of Amlodipine and Atenolol
- Amlodipine is a dihydropyridine calcium antagonist
- Peripheral vasodilator
- Amlodipine reduces tone and coronary vasoreactivity
- Atenolol is a cardioselective beta-blocker
- Reduction in blood pressure
- Reduction in cardiac output
- Negative inotropic and negative chronotropic effects of Atenolol
Dosage & Administration
- Recommended dosage of Amlodipine and Atenolol 5/25 mg tablet once daily
- Dosage may be increased to 5/25 mg two tablets daily or as advised by physicians
- Individualized dosage
Interaction
- Atenolol reduces the clearance of disopyramide by 20%
- Additive negative inotropic effects with disopyramide
- Ampicillin may reduce Atenolol levels
- Beta-blockers may decrease tissue sensitivity to insulin
- Atenolol has less potential for inhibiting insulin secretion
Contraindications
- Hypersensitivity to either component
- Sinus bradycardia
- Second and higher degrees of heart block
- Cardiogenic shock
- Hypotension
- Congestive heart failure
- Poor left ventricular function
Side Effects
- Well tolerated combination
- Side-effects include fatigue, headache, edema, nausea, drowsiness, anxiety, and depression
Pregnancy & Lactation
- Use during pregnancy if expected benefit outweighs potential fetal risk
- Not recommended for nursing mothers
- Breast-feeding should be stopped if use is considered necessary
Precautions & Warnings
- Use with caution in patients with airway obstruction
- Can be used in patients with renal impairment
- Caution with creatinine clearance less than 30 ml/min
- Caution in patients with severe liver damage
- Warn patients against sudden drug withdrawal
- Discontinuation should be gradual and under observation
Overdose Effects
- Hypotension and congestive cardiac failure may occur
- Unabsorbed drugs may be removed by gastric lavage or administration of activated charcoal
- Symptomatic treatment suggested
Therapeutic Class
- Combined antihypertensive preparations
Storage Conditions
- Keep below 30°C temperature
- Away from light & moisture
- Keep out of the reach of children