Traxon 1 gm/vial (IV Injection)

1 gm vial: ৳ 250.00

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Opsonin pharma ltd
Also available as
Traxon 250 mg injection Traxon 500 mg injection Traxon 1 gm injection Traxon 250 mg injection Traxon 500 mg injection Traxon 2 gm injection

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

Ceftriaxone is a 3rd generation broad-spectrum parenteral cephalosporin antibiotic with potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. It interferes with the synthesis of the bacterial cell wall and has a long plasma elimination half-life of about 6 to 9 hours. It is not metabolized in the body and is highly protein bound (95%).

Dosage

  • Adult:
    • 1 to 2 gm by intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
    • Maximum dose: 4 gm/day
  • Specific Adult Uses:
    • Uncomplicated gonococcal infections: 250 mg IM as a single dose
    • Surgical prophylaxis: 1 g IV as a single dose 30 to 120 minutes before surgery
    • Duration of therapy: 4 to 14 days; in complicated infections, longer therapy may be required
  • Infants and Children:
    • 50 to 75 mg/kg intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
    • Maximum dose: 2 gm/day

Administration

  • Intramuscular Injection: 250 mg or 500 mg Ceftriaxone should be dissolved in Lidocaine HCI 1% injection; 1 g Ceftriaxone in 3.5 ml of Lidocaine HCI 1% injection
  • Intravenous Injection: 250 mg or 500 mg Ceftriaxone should be dissolved in Water for injection; 1 g Ceftriaxone in 10 ml of Water for injection USP; 2 g Ceftriaxone in 20 ml of Water for injection
  • Injection Administration: Intramuscular or Intravenous injection or tubing infusion over a period of 30 minutes at concentration between 10 mg/mL and 40 mg/mL

Interaction

No drug interactions reported

Contraindications

Patients with a history of hypersensitivity to cephalosporin antibiotics

Side Effects

  • Gastro-intestinal effects including diarrhea, nausea and vomiting
  • Cutaneous reactions including rash, pruritus, urticaria, edema and erythema multiforme
  • Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia and neutropenia
  • Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
  • CNS reactions including nervousness, confusion, sleep disturbances, headache, hyperactivity, convulsion, hypertonia and dizziness
  • Local phlebitis occurs rarely following intravenous administration but can be minimized by slow injections over 2-4 minutes

Pregnancy & Lactation

Not established in pregnancy; caution in lactating mothers

Precautions & Warnings

  • Anaphylactic shock
  • Shadows suggesting sludge in the gallbladder detected by sonograms
  • Blood picture should be checked at regular intervals during prolonged treatment

Use in Special Populations

Not to be given to neonates if premature and newborn (up to 28 days of age)

Overdose Effects

No specific antidote; symptomatic treatment

Therapeutic Class

Third generation Cephalosporins

Storage Conditions

Vial store in a cool, dry place (below 30° C), away from light & moisture; Keep out of the reach of children

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