Triject 250 mg/vial (IM Injection)

250 mg vial: ৳ 120.00

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Eskayef pharmaceuticals ltd
Also available as
Triject 500 mg injection Triject 1 gm injection Triject 500 mg injection Triject 1 gm injection Triject 2 gm injection

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

Ceftriaxone is a 3rd generation broad-spectrum parenteral cephalosporin antibiotic with potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. It interferes with the synthesis of the bacterial cell wall and has a long plasma elimination half-life of about 6 to 9 hours.

Dosage

  • Adult dosage: 1 to 2 gm by intravenous or intramuscular administration once a day or in equally divided doses twice a day
  • Maximum adult dose: 4 gm/day
  • Uncomplicated gonococcal infections: 250 mg intramuscular as a single dose
  • Surgical prophylaxis: 1 g intravenous as a single dose
  • Infants and Children dosage: 50 to 75 mg/kg intravenous or intramuscular administration once a day or in equally divided doses twice a day

Administration

  • Preparation of Solutions for Intramuscular/Intravenous Injections
  • Intramuscular Injection: 250 mg or 500 mg Ceftriaxone dissolved in Lidocaine HCI 1% injection; 1 g Ceftriaxone in 3.5 ml of Lidocaine HCI 1% injection
  • Intravenous Injection: 250 mg or 500 mg Ceftriaxone dissolved in Water for injection; 1 g Ceftriaxone in 10 ml of Water for injection USP; 2 g Ceftriaxone in 20 ml of Water for injection

Interaction

No drug interactions reported

Contraindications

Ceftriaxone should not be given to patients with a history of hypersensitivity to cephalosporin antibiotics

Side Effects

  • gastro-intestinal effects including diarrhea, nausea, and vomiting
  • cutaneous reactions including rash, pruritus, urticaria, edema, and erythema multiforme
  • hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia, and neutropenia
  • hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
  • CNS reactions including nervousness, confusion, sleep disturbances, headache, hyperactivity, convulsion, hypertonia, and dizziness
  • Local phlebitis occurs rarely following intravenous administration

Pregnancy & Lactation

Safety in human pregnancy has not been established. Caution should be exercised when administered to lactating mothers

Precautions & Warnings

Anaphylactic shock, gallbladder sludge shadows, and blood picture should be checked during prolonged treatment

Use in Special Populations

Must not be given to neonates if premature and newborn (up to 28 days of age)

Overdose Effects

No specific antidote. Treatment should be symptomatic

Therapeutic Class

Third generation Cephalosporins

Storage Conditions

Vial to be stored in a cool, dry place below 30°C, away from light & moisture, and out of the reach of children

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