Triject 500 mg/vial (IM Injection)

500 mg vial: ৳ 180.00

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Eskayef pharmaceuticals ltd
Also available as
Triject 250 mg injection Triject 1 gm injection Triject 500 mg injection Triject 1 gm injection Triject 2 gm injection

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

  • Broad-spectrum parenteral cephalosporin antibiotic
  • Bactericidal activity against wide range of Gram-positive and Gram-negative organisms
  • Interferes with synthesis of bacterial cell wall
  • High stability in presence of beta lactamases
  • Long plasma elimination half-life (6 to 9 hours)
  • Not metabolized in the body
  • Highly protein bound (95%)

Dosage

  • Usual dose for adults: 1 to 2 gm by intravenous or intramuscular administration once a day
  • Maximum dose for adults: 4 gm/day
  • Usual dose for infants and children: 50 to 75 mg/kg intravenous or intramuscular administration once a day
  • Maximum dose for infants and children: 2 gm/day
  • Duration of therapy: 4 to 14 days
  • Patient tolerance test recommended before starting treatment

Administration

  • Preparation of solutions for intramuscular / intravenous injections
  • Intramuscular injection: Ceftriaxone should be dissolved in Lidocaine HCI 1% injection
  • Intravenous injection: Ceftriaxone should be dissolved in Water for injection
  • Administration over 2-4 minutes for intramuscular or intravenous injection or by tubing infusion over a period of 30 minutes
  • Patient tolerance test recommended before starting treatment
  • Freshly reconstituted solution recommended

Interaction

  • No reported drug interactions

Contraindications

  • Not for patients with history of hypersensitivity to cephalosporin antibiotics

Side Effects

  • Gastro-intestinal effects including diarrhea, nausea, vomiting, stomatitis, glossitis
  • Cutaneous reactions including rash, pruritus, urticaria, edema, erythema multiforme
  • Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia, neutropenia
  • Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
  • CNS reactions including nervousness, confusion, sleep disturbances, headache, hyperactivity, convulsion, hypertonia, dizziness
  • Local phlebitis occurs rarely following intravenous administration

Pregnancy & Lactation

  • Safety not established in human pregnancy
  • Caution should be exercised when administered to a lactating mother

Precautions & Warnings

  • Anaphylactic shock cannot be ruled out
  • Gallbladder sludge may be detected in rare cases
  • Blood picture should be checked at regular intervals during prolonged treatment

Use in Special Populations

  • Must not be given to neonates if premature and newborn (up to 28 days of age)

Overdose Effects

  • No specific antidote
  • Treatment should be symptomatic

Therapeutic Class

  • Third generation Cephalosporins

Storage Conditions

  • Store in a cool, dry place (below 30°C), away from light & moisture
  • Keep out of the reach of children

Related Brands