Triject 500 mg/vial (IV Injection)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ceftriaxone sodium |
| Company | Eskayef pharmaceuticals ltd |
| Also available as |
Indications
- Lower respiratory tract infections
- Acute Bacterial Otitis Media
- Skin and skin structure infections
- Urinary tract infections
- Gonorrhea
- Bacterial Septicemia
- Bone and joint infections
- Meningitis
- Prevention of postoperative infections
- Perioperative prophylaxis of infections associated with surgery
Pharmacology
Ceftriaxone is a 3rd generation broad-spectrum parenteral cephalosporin antibiotic. It has potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. It kills bacteria by interfering with the synthesis of the bacterial cell wall. Ceftriaxone has a long plasma elimination half-life of about 6 to 9 hours. It is not metabolized in the body.
Dosage
- Adult: 1 to 2 gm by intravenous administration once a day
- Infants and Children: 50 to 75 mg/kg intravenous administration once a day
- Duration of therapy: 4 to 14 days; longer in complicated infections
Administration
- Preparation of Solutions for Intramuscular / Intravenous Injections
- Injection should be administered over 2-4 minutes
- Patient tolerance test should be checked by administration of a test dose
Interaction
No drug interactions reported
Contraindications
Ceftriaxone should not be given to patients with a history of hypersensitivity to cephalosporin antibiotics
Side Effects
- gastro-intestinal effects including diarrhea, nausea, and vomiting
- cutaneous reactions including rash, pruritus, urticaria
- hematologic reactions including eosinophilia, thrombocytopenia
- hepatic reactions including elevations of SGOT or SGPT
- CNS reactions including nervousness, confusion
- Local phlebitis occurs rarely following intravenous administration
Pregnancy & Lactation
Safety in human pregnancy not established; caution should be exercised when administered to a lactating mother
Precautions & Warnings
- Anaphylactic shock cannot be ruled out
- Shadows suggesting sludge have been detected by sonograms of the gallbladder
- Blood picture should be checked at regular intervals during prolonged treatment
Use in Special Populations
Must not be given to neonates if premature and newborn (up to 28 days of age)
Overdose Effects
No specific antidote. Treatment should be symptomatic
Therapeutic Class
Third generation Cephalosporins
Storage Conditions
Store in a cool, dry place (below 30°C), away from light & moisture. Keep out of the reach of children