Triject 1 gm/vial (IV Injection)

1 gm vial: ৳ 250.00

Medicine Details

Category	Details
Generic	Ceftriaxone sodium
Company	Eskayef pharmaceuticals ltd
Also available as	Triject 250 mg injection Triject 500 mg injection Triject 1 gm injection Triject 500 mg injection Triject 2 gm injection

Indications

Lower respiratory tract infections
Acute Bacterial Otitis Media
Skin and skin structure infections
Urinary tract infections
Gonorrhea
Bacterial Septicemia
Bone and joint infections
Meningitis
Prevention of postoperative infections
Perioperative prophylaxis of infections associated with surgery

Pharmacology

Ceftriaxone is a 3rd generation broad-spectrum parenteral cephalosporin antibiotic with potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. It kills bacteria by interfering with the synthesis of the bacterial cell wall. Ceftriaxone has a relatively long plasma elimination half-life of about 6 to 9 hours, making single or once-daily dosage appropriate for most patients. It is not metabolized in the body and is highly protein bound (95%).

Dosage

Adult:
- 1 to 2 gm by intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
- Maximum dose: 4 gm/day
Uncomplicated gonococcal infections: 250 mg IM as a single dose
Surgical prophylaxis: 1 g IV as a single dose 30 to 120 minutes before surgery
Infants and Children (01 month or older):
- 50 to 75 mg/kg intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
- Maximum dose: 2 gm/day
Duration of therapy: Continue for more than 2 days after signs and symptoms of infection have disappeared. Usual duration is 4 to 14 days; in complicated infections, longer therapy may be required.

Administration

Intramuscular Injection:
- 250 mg or 500 mg Ceftriaxone should be dissolved in 2 ml or 3.5 ml of Lidocaine HCI 1% injection
- Injection should be administered over 2-4 minutes
Intravenous Injection:
- 250 mg or 500 mg Ceftriaxone should be dissolved in 5 ml of Water for Injection
- 1 g Ceftriaxone in 10 ml of Water for Injection USP
- 2 g Ceftriaxone in 20 ml of Water for Injection
- Injection should be administered over 30 minutes at a concentration between 10 mg/mL and 40 mg/mL

Interaction

No drug interactions have been reported.

Contraindications

Ceftriaxone should not be given to patients with a history of hypersensitivity to cephalosporin antibiotics.

Side Effects

Gastro-intestinal effects including diarrhea, nausea, vomiting, stomatitis, and glossitis
Cutaneous reactions including rash, pruritus, urticaria, edema, and erythema multiforme
Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia, and neutropenia
Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
CNS reactions including nervousness, confusion, sleep disturbances, headache, hyperactivity, convulsion, hypertonia, and dizziness
Local phlebitis occurs rarely following intravenous administration but can be minimized by slow injections over 2-4 minutes.

Pregnancy & Lactation

Safety in human pregnancy has not been established. It should not be used in pregnancy unless absolutely indicated. Low concentrations of Ceftriaxone are excreted in human milk, so caution should be exercised when administered to a lactating mother.

Precautions & Warnings

Anaphylactic shock cannot be ruled out even if a thorough patient history is taken
During prolonged treatment, the blood picture should be checked at regular intervals.

Use in Special Populations

Triject must not be given to neonates if the neonate is premature and newborn (up to 28 days of age).

Overdose Effects

There is no specific antidote. Treatment of overdosage should be symptomatic.

Therapeutic Class

Third generation Cephalosporins

Storage Conditions

Vial should be stored in a cool, dry place (below 30°C), away from light and moisture. Keep out of the reach of children.