Triject 2 gm/vial (IV Injection)

2 gm vial: ৳ 350.00

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Eskayef pharmaceuticals ltd
Also available as
Triject 250 mg injection Triject 500 mg injection Triject 1 gm injection Triject 500 mg injection Triject 1 gm injection

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

  • Broad-spectrum parenteral cephalosporin antibiotic
  • Bactericidal activity against a wide range of Gram-positive and Gram-negative organisms
  • Interferes with bacterial cell wall synthesis
  • High stability in the presence of beta lactamases
  • Long plasma elimination half-life of about 6 to 9 hours
  • Not metabolized in the body
  • Excretion in urine and feces
  • Highly protein bound (95%)

Dosage

  • 1 to 2 gm by intravenous or intramuscular administration once a day (or in equally divided doses twice a day) for adults
  • 250 mg IM as a single dose for uncomplicated gonococcal infections
  • Duration of therapy: 4 to 14 days for adults
  • 50 to 75 mg/kg intravenous or intramuscular administration once a day (or in equally divided doses twice a day) for infants and children (01 month or older)
  • Duration of therapy: Continue for more than 2 days after signs and symptoms of infection have disappeared for infants and children
  • Maximum dose: 4 gm/day for adults
  • Maximum dose: 2 gm/day for infants and children

Administration

  • Preparation of Solutions for Intramuscular / Intravenous Injections
  • Injection should be administered over 2-4 minutes
  • Patient tolerance test should be checked by administration of a test dose
  • Freshly reconstituted solution is recommended
  • Maintains potency for at least 6 hours at room temperature or 24 hours at 5°C

Interaction

  • No drug interactions reported

Contraindications

  • Patients with a history of hypersensitivity to cephalosporin antibiotics

Side Effects

  • Gastro-intestinal effects including diarrhea, nausea and vomiting
  • Cutaneous reactions including rash, pruritus, urticaria, edema and erythema multiforme
  • Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia and neutropenia
  • Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
  • CNS reactions including nervousness, confusion, sleep disturbances
  • Headache, hyperactivity, convulsion, hypertonia and dizziness
  • Local phlebitis occurs rarely following intravenous administration

Pregnancy & Lactation

  • Safety in human pregnancy not established
  • Caution should be exercised when administered to a lactating mother

Precautions & Warnings

  • Anaphylactic shock cannot be ruled out
  • Shadows suggesting sludge have been detected by sonograms of the gallbladder in rare cases
  • Blood picture should be checked at regular intervals during prolonged treatment

Use in Special Populations

  • Must not be given to neonates if premature and newborn (up to 28 days of age)

Overdose Effects

  • No specific antidote
  • Treatment should be symptomatic

Therapeutic Class

  • Third generation Cephalosporins

Storage Conditions

  • Store in a cool, dry place (below 30°C)
  • Away from light & moisture
  • Keep out of the reach of children

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