Trimax 1 gm/vial (IM Injection)
1 gm vial: ৳ 160.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Ceftriaxone sodium |
| Company | Pharmasia limited |
| Also available as |
Indications
- Lower respiratory tract infections
- Acute Bacterial Otitis Media
- Skin and skin structure infections
- Urinary tract infections
- Gonorrhea
- Bacterial Septicemia
- Bone and joint infections
- Meningitis
- Prevention of postoperative infections
- Perioperative prophylaxis of infections associated with surgery
Pharmacology
- Broad-spectrum parenteral cephalosporin antibiotic
- Bactericidal activity against Gram-positive and Gram-negative organisms
- Interferes with bacterial cell wall synthesis
- High stability in the presence of beta lactamases
- Long plasma elimination half-life of 6 to 9 hours
- Not metabolized in the body
- Excretion in urine and feces
- Highly protein bound (95%)
Dosage
- Usual adult dose of 1 to 2 gm by intravenous or intramuscular administration once a day
- Maximum dose of 4 gm/day for certain infections
- Usual pediatric dose of 50 to 75 mg/kg intravenous or intramuscular administration once a day
- Maximum pediatric dose of 2 gm/day for certain infections
- Duration of therapy: 4 to 14 days
Administration
- Preparation of solutions for intramuscular / intravenous injections
- Injection administered over 2-4 minutes
- Patient tolerance test recommended
- Potency maintained for at least 6 hours at room temperature or 24 hours at 5°C
Interaction
- No reported drug interactions
Contraindications
- Not to be given to patients with hypersensitivity to cephalosporin antibiotics
Side Effects
- Gastro-intestinal effects including diarrhea, nausea, and vomiting
- Cutaneous reactions including rash, pruritus, and urticaria
- Hematologic reactions including eosinophilia, thrombocytopenia, and anemia
- Hepatic reactions including elevations of liver enzymes
- CNS reactions including nervousness, confusion, and sleep disturbances
- Local phlebitis following intravenous administration
Pregnancy & Lactation
- Safety in human pregnancy not established
- Caution in lactating mothers due to low concentrations excreted in human milk
Precautions & Warnings
- Risk of anaphylactic shock
- Potential gallbladder sludge
- Regular blood picture check during prolonged treatment
Use in Special Populations
- Not to be given to neonates if premature and newborn (up to 28 days of age)
Overdose Effects
- No specific antidote
- Symptomatic treatment recommended
Therapeutic Class
- Third generation Cephalosporins
Storage Conditions
- Vial should be stored in a cool, dry place below 30°C, away from light and moisture