Triphin 500 mg/vial (IM Injection)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ceftriaxone sodium |
| Company | Ziska pharmaceuticals ltd |
| Also available as |
Indications
- Lower respiratory tract infections
- Acute Bacterial Otitis Media
- Skin and skin structure infections
- Urinary tract infections
- Gonorrhea
- Bacterial Septicemia
- Bone and joint infections
- Meningitis
- Prevention of postoperative infections
- Perioperative prophylaxis of infections associated with surgery
Pharmacology
Ceftriaxone is a 3rd generation broad-spectrum parenteral cephalosporin antibiotic with potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. It kills bacteria by interfering with the synthesis of the bacterial cell wall. It has a relatively long plasma elimination half-life of about 6 to 9 hours, and is highly protein bound (95%).
Dosage
- Adult: 1 to 2 gm by intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
- Infants and Children (01 month or older): 50 to 75 mg/kg intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
- Duration of therapy: 4 to 14 days; in complicated infections, longer therapy may be required
Administration
- Intramuscular Injection: Dissolve in Lidocaine HCI 1% injection
- Intravenous Injection: Dissolve in Water for injection
- Preparation time: 2-4 minutes for injection, 30 minutes for tubing infusion
Interaction
No drug interactions reported
Contraindications
Patients with a history of hypersensitivity to cephalosporin antibiotics
Side Effects
- Diarrhea
- Nausea
- Vomiting
- Rash
- Pruritus
- Urticaria
- Eosinophilia
- Thrombocytopenia
- Leucopenia
- Anemia
- Local phlebitis
Pregnancy & Lactation
Safety in human pregnancy not established. Caution with lactating mothers.
Precautions & Warnings
- Anaphylactic shock
- Gallbladder sludge
- Regular blood picture checks during prolonged treatment
Use in Special Populations
Must not be given to neonates if premature and newborn (up to 28 days of age)
Overdose Effects
No specific antidote. Treatment should be symptomatic
Therapeutic Class
- Third generation Cephalosporins
Storage Conditions
Store in a cool, dry place below 30°C, away from light & moisture. Keep out of the reach of children