Triphin 1 gm/vial (IM Injection)
1 gm vial: ৳ 160.48
Medicine Details
| Category | Details |
|---|---|
| Generic | Ceftriaxone sodium |
| Company | Ziska pharmaceuticals ltd |
| Also available as |
Indications
- Lower respiratory tract infections
- Acute Bacterial Otitis Media
- Skin and skin structure infections
- Urinary tract infections
- Gonorrhea
- Bacterial Septicemia
- Bone and joint infections
- Meningitis
- Prevention of postoperative infections
- Perioperative prophylaxis of infections associated with surgery
Pharmacology
- Bactericidal activity against a wide range of Gram-positive and Gram-negative organisms
- Interferes with the synthesis of the bacterial cell wall
- High stability in the presence of beta lactamases
- Long plasma elimination half-life (6 to 9 hours)
- Not metabolized in the body
- High degree of protein binding (95%)
- Excretion in urine and bile
Dosage
- Usual dose for adults (1 to 2 gm by intravenous or intramuscular administration once a day)
- Dosing based on infection type
- Specific doses for uncomplicated gonococcal infections and surgical prophylaxis
- Usual dose for infants and children (50 to 75 mg/kg intravenous or intramuscular administration once a day)
Administration
- Preparation of solutions for intramuscular and intravenous injections
- Administration time and concentration guidelines
- Recommendation for a patient tolerance test before treatment
Interaction
- No reported drug interactions
Contraindications
- Not to be given to patients with a history of hypersensitivity to cephalosporin antibiotics
Side Effects
- Gastro-intestinal effects (diarrhea, nausea, vomiting, etc.)
- Cutaneous reactions (rash, pruritus, urticaria, etc.)
- Hematologic reactions (eosinophilia, thrombocytopenia, etc.)
- Hepatic reactions (elevations of SGOT or SGPT, bilirubinemia)
- CNS reactions (nervousness, confusion, sleep disturbances, etc)
- Local phlebitis following intravenous administration
Pregnancy & Lactation
- Safety in human pregnancy not established
- Caution advised when administered to lactating mothers
Precautions & Warnings
- Potential for anaphylactic shock
- Rare cases of gallbladder shadows detected
- Recommend blood picture checks during prolonged treatment
Use in Special Populations
- Must not be given to neonates if premature and newborn (up to 28 days of age)
Overdose Effects
- No specific antidote
- Treatment should be symptomatic
Therapeutic Class
- Third generation Cephalosporins
Storage Conditions
- Store in a cool, dry place (below 30°C), away from light & moisture
- Keep out of the reach of children