Triphin 250 mg/vial (IV Injection)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ceftriaxone sodium |
| Company | Ziska pharmaceuticals ltd |
| Also available as |
Indications
- Lower respiratory tract infections
- Acute Bacterial Otitis Media
- Skin and skin structure infections
- Urinary tract infections
- Gonorrhea
- Bacterial Septicemia
- Bone and joint infections
- Meningitis
- Prevention of postoperative infections
- Perioperative prophylaxis of infections associated with surgery
Pharmacology
Ceftriaxone is a 3rd generation broad-spectrum parenteral cephalosporin antibiotic with potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. It kills bacteria by interfering with the synthesis of the bacterial cell wall. Ceftriaxone has a high degree of stability in the presence of beta lactamases and a relatively long plasma elimination half-life of about 6 to 9 hours.
Dosage
- 1 to 2 gm by intravenous or intramuscular administration once a day
- 250 mg IM for uncomplicated gonococcal infections
- Doses for infants and children
- Duration of therapy: 4 to 14 days
Administration
- Preparation for Intramuscular / Intravenous Injections
- Injection should be administered over specific durations
Interaction
No drug interactions reported
Contraindications
Should not be given to patients with a history of hypersensitivity to cephalosporin antibiotics
Side Effects
- Gastro-intestinal effects including diarrhea, nausea, and vomiting
- Cutaneous reactions including rash, pruritus, and urticaria
- Hematologic reactions including eosinophilia, thrombocytopenia, and leucopenia
- Hepatic reactions including elevations of SGOT or SGPT
- CNS reactions including nervousness, sleep disturbances, and headache
- Rare cases of local phlebitis following intravenous administration
Pregnancy & Lactation
Safety in human pregnancy not established. Low concentrations excreted in human milk.
Precautions & Warnings
- Anaphylactic shock precautions
- Gallbladder sludge findings in rare cases
- Regular blood picture check during prolonged treatment
Use in Special Populations
Must not be given to neonates if the neonate is premature and newborn (up to 28 days of age)
Overdose Effects
No specific antidote. Treatment should be symptomatic.
Therapeutic Class
Third generation Cephalosporins
Storage Conditions
Cool, dry place (below 30°C), away from light & moisture, Keep out of the reach of children