Triphin 500 mg/vial (IV Injection)

500 mg vial: ৳ 120.37

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Ziska pharmaceuticals ltd
Also available as
Triphin 250 mg injection Triphin 500 mg injection Triphin 1 gm injection Triphin 250 mg injection Triphin 1 gm injection Triphin 2 gm injection

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

  • Broad-spectrum parenteral cephalosporin antibiotic
  • Bactericidal activity against a wide range of Gram-positive and Gram-negative organisms
  • Long plasma elimination half-life of about 6 to 9 hours
  • High stability in the presence of beta lactamases
  • Not metabolized in the body
  • Excretion in urine and bile
  • Highly protein bound (95%)

Dosage

  • Adult dose: 1 to 2 gm by intravenous or intramuscular administration once a day
  • Maximum adult dose: 4 gm/day
  • Uncomplicated gonococcal infections: 250 mg IM as a single dose
  • Surgical prophylaxis: 1 g IV as a single dose 30 to 120 minutes before surgery
  • Infants and Children dose: 50 to 75 mg/kg intravenous or intramuscular administration once a day
  • Maximum pediatric dose: 2 gm/day
  • Duration of therapy: 4 to 14 days

Administration

  • Preparation of Solutions for Intramuscular / Intravenous Injections
  • Multiple options for dissolving Ceftriaxone for Intramuscular or Intravenous Injection
  • Recommended administration over 2-4 minutes by Intramuscular or Intravenous injection

Interaction

  • No drug interactions reported

Contraindications

  • History of hypersensitivity to cephalosporin antibiotics

Side Effects

  • Gastro-intestinal effects including diarrhea, nausea and vomiting, stomatitis and glossitis
  • Cutaneous reactions including rash, pruritus, urticaria, edema and erythema multiforme
  • Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia and neutropenia
  • Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
  • CNS reactions including nervousness, confusion, sleep disturbances, headache, hyperactivity, convulsion, hypertonia and dizziness
  • Local phlebitis occurs rarely following intravenous administration

Pregnancy & Lactation

  • Safety in human pregnancy not established
  • Use in pregnancy only if absolutely indicated
  • Low concentrations of Ceftriaxone excreted in human milk
  • Caution when administered to a lactating mother

Precautions & Warnings

  • Anaphylactic shock possibility
  • Shadows suggesting sludge in the gallbladder in rare cases
  • Regular blood picture checks during prolonged treatment

Use in Special Populations

  • Not to be given to premature and newborn neonates

Overdose Effects

  • No specific antidote. Treatment should be symptomatic

Therapeutic Class

  • Third generation Cephalosporins

Storage Conditions

  • Store in a cool, dry place (below 30°C), away from light & moisture

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