Triphin 1 gm/vial (IV Injection)

1 gm vial: ৳ 160.48

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Ziska pharmaceuticals ltd
Also available as
Triphin 250 mg injection Triphin 500 mg injection Triphin 1 gm injection Triphin 250 mg injection Triphin 500 mg injection Triphin 2 gm injection

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

  • Broad-spectrum antibiotic
  • Potent bactericidal activity
  • Interferes with bacterial cell wall synthesis
  • Long plasma elimination half-life
  • Not metabolized in the body
  • Highly protein bound (95%)

Dosage

  • Adult dose: 1 to 2 gm by intravenous or intramuscular administration once a day
  • Usual duration of therapy: 4 to 14 days
  • Infants and Children dose: 50 to 75 mg/kg intravenous or intramuscular administration once a day
  • Duration of therapy: Continue for more than 2 days after signs and symptoms of infection have disappeared

Administration

  • Preparation of Solutions for Intramuscular / Intravenous Injections
  • Administered over 2-4 minutes
  • Patient tolerance test should be checked by administration of a test dose
  • Maintains potency for at least 6 hours at room temperature or 24 hours at 5°C

Interaction

  • No drug interactions reported

Contraindications

  • Hypersensitivity to cephalosporin antibiotics

Side Effects

  • Gastrointestinal effects including diarrhea, nausea and vomiting
  • Cutaneous reactions including rash, pruritus, urticaria
  • Hematologic reactions including eosinophilia, thrombocytopenia
  • Hepatic reactions including elevations of SGOT or SGPT
  • CNS reactions including nervousness, confusion, headache
  • Local phlebitis occurs rarely following intravenous administration

Pregnancy & Lactation

  • Safety in human pregnancy not established
  • Caution should be exercised when administered to a lactating mother

Precautions & Warnings

  • Anaphylactic shock cannot be ruled out
  • Shadows suggesting sludge have been detected by sonograms of the gallbladder
  • Blood picture should be checked at regular intervals during prolonged treatment

Use in Special Populations

  • Must not be given to neonates if premature and newborn (up to 28 days of age)

Overdose Effects

  • No specific antidote. Treatment should be symptomatic

Therapeutic Class

  • Third generation Cephalosporins

Storage Conditions

  • Vial store in a cool, dry place (below 30°C)

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