Triphin 2 gm/vial (IV Injection)
2 gm vial: ৳ 250.75
Medicine Details
| Category | Details |
|---|---|
| Generic | Ceftriaxone sodium |
| Company | Ziska pharmaceuticals ltd |
| Also available as |
Indications
- Lower respiratory tract infections
- Acute Bacterial Otitis Media
- Skin and skin structure infections
- Urinary tract infections
- Gonorrhea
- Bacterial Septicemia
- Bone and joint infections
- Meningitis
- Prevention of postoperative infections
- Perioperative prophylaxis of infections associated with surgery
Pharmacology
- Broad-spectrum parenteral cephalosporin antibiotic
- Potent bactericidal activity against Gram-positive and Gram-negative organisms
- Interferes with synthesis of bacterial cell wall
- High stability in the presence of beta lactamases
- Long plasma elimination half-life of about 6 to 9 hours
- Not metabolized in the body
- Excretion: 40-65% unchanged in urine, remainder in bile and feces
- Highly protein bound (95%)
Dosage
- Adult dose: 1 to 2 gm by intravenous or intramuscular administration once a day
- Maximum adult dose: 4 gm/day
- Pediatric dose: 50 to 75 mg/kg intravenous or intramuscular administration once a day
- Maximum pediatric dose: 2 gm/day
- Duration of therapy: 4 to 14 days
Administration
- For intramuscular injection: Dissolution in Lidocaine HCI 1% injection
- For intravenous injection: Dissolution in Water for injection
- Administration over 2-4 minutes
- Patient tolerance test recommended
- Freshly reconstituted solution recommended
Interaction
- No reported drug interactions
Contraindications
- Hypersensitivity to cephalosporin antibiotics
Side Effects
- Gastro-intestinal effects including diarrhea, nausea, vomiting, stomatitis, and glossitis
- Cutaneous reactions including rash, pruritus, urticaria, edema, and erythema multiforme
- Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia, and neutropenia
- Hepatic reactions including elevations of SGOT or SGPT, and bilirubinemia
- CNS reactions including nervousness, confusion, sleep disturbances, headache, and dizziness
- Local phlebitis occurs rarely following intravenous administration
Pregnancy & Lactation
- Safety in human pregnancy not established
- Caution in lactating mothers
Precautions & Warnings
- Potential for anaphylactic shock
- Gallbladder sludge detected in rare cases
- Regular blood picture check during prolonged treatment
Use in Special Populations
- Avoid in premature and newborn neonates (up to 28 days of age)
Overdose Effects
- No specific antidote
- Symptomatic treatment
Therapeutic Class
- Third generation Cephalosporins
Storage Conditions
- Store in a cool, dry place (below 30°C)
- Keep away from light and moisture
- Keep out of the reach of children