Trizon 250 mg/vial (IM Injection)

250 mg vial: ৳ 100.30

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Acme laboratories ltd
Also available as
Trizon 500 mg injection Trizon 1 gm injection Trizon 500 mg injection Trizon 1 gm injection Trizon 2 gm injection

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

  • Bactericidal activity against wide range of Gram-positive and Gram-negative organisms
  • Interferes with synthesis of bacterial cell wall
  • High stability in presence of beta lactamases
  • Relatively long plasma elimination half-life of about 6 to 9 hours
  • Not metabolized in the body
  • Highly protein bound (95%)

Dosage

  • Adult:
    • 1 to 2 gm by intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
    • Maximum dose: 4 gm/day
  • Infants and Children (01 month or older):
    • 50 to 75 mg/kg intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
    • Maximum dose: 2 gm/day
  • Duration of therapy: Continue for more than 2 days after signs and symptoms of infection have disappeared. Usual duration is 4 to 14 days; in complicated infections, longer therapy may be required.

Administration

  • Preparation of solutions for intramuscular / intravenous injections
  • Administration over 2-4 minutes
  • Check patient tolerance test by administration of a test dose
  • Recommended freshly reconstituted solution
  • Maintains potency for at least 6 hours at room temperature or 24 hours at 5°C

Interaction

No drug interactions have been reported

Contraindications

Ceftriaxone should not be given to patients with a history of hypersensitivity to cephalosporin antibiotics

Side Effects

  • Gastro-intestinal effects including diarrhea, nausea and vomiting, stomatitis and glossitis
  • Cutaneous reactions including rash, pruritus, urticaria, edema and erythema multiforme
  • Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia and neutropenia
  • Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
  • CNS reactions including nervousness, confusion, sleep disturbances, headache, hyperactivity, convulsion, hypertonia and dizziness
  • Rare occurrence of local phlebitis following intravenous administration

Pregnancy & Lactation

  • Safety in human pregnancy not established
  • Not recommended for use in pregnancy unless absolutely indicated
  • Low concentrations of Ceftriaxone excreted in human milk
  • Caution should be exercised when administered to a lactating mother

Precautions & Warnings

  • Anaphylactic shock cannot be ruled out
  • Immediate countermeasures such as intravenous epinephrine followed by a glucocorticoid required for anaphylactic shock
  • Rare cases of shadows suggesting sludge detected by sonograms of the gallbladder
  • Regular blood picture checks during prolonged treatment

Use in Special Populations

Trizon must not be given to neonates if premature and newborn (up to 28 days of age)

Overdose Effects

No specific antidote. Treatment should be symptomatic

Therapeutic Class

Third generation Cephalosporins

Storage Conditions

Vial store in a cool, dry place (below 30°C), away from light & moisture. Keep out of the reach of children

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