Trizon 500 mg/vial (IV Injection)
500 mg vial: ৳ 130.39
Medicine Details
| Category | Details |
|---|---|
| Generic | Ceftriaxone sodium |
| Company | Acme laboratories ltd |
| Also available as |
Indications
- Lower respiratory tract infections
- Acute Bacterial Otitis Media
- Skin and skin structure infections
- Urinary tract infections
- Gonorrhea
- Bacterial Septicemia
- Bone and joint infections
- Meningitis
- Prevention of postoperative infections
- Perioperative prophylaxis of infections associated with surgery
Pharmacology
- Broad-spectrum antibiotic
- Bactericidal activity
- Gram-positive and Gram-negative organisms
- Interferes with bacterial cell wall synthesis
- Stable in the presence of beta lactamases
- Long plasma elimination half-life
- Not metabolized in the body
Dosage
- Adult dosage: 1 to 2 gm by intravenous or intramuscular administration once a day or twice a day
- Infants and Children dosage: 50 to 75 mg/kg intravenous or intramuscular administration once a day or twice a day
- Maximum dosage: 4 gm/day for adults and 2 gm/day for children
- Duration of therapy: 4 to 14 days or longer for complicated infections
Administration
- Preparation of solutions for intramuscular / intravenous injections
- Administration over 2-4 minutes
- Tubing infusion over a period of 30 minutes
- Patient tolerance test recommended before starting treatment
- Freshly reconstituted solution recommended
- Maintains potency for at least 6 hours at room temperature or 24 hours at 5°C
Interaction
- No reported drug interactions
Contraindications
- Hypersensitivity to cephalosporin antibiotics
Side Effects
- Gastro-intestinal effects including diarrhea, nausea, vomiting, stomatitis and glossitis
- Cutaneous reactions including rash, pruritus, urticaria, edema and erythema multiforme
- Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia and neutropenia
- Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
- CNS reactions including nervousness, confusion, sleep disturbances, headache, hyperactivity, convulsion, hypertonia and dizziness
- Local phlebitis following intravenous administration
Pregnancy & Lactation
- Safety in human pregnancy not established
- Caution recommended when administered to lactating mothers
Precautions & Warnings
- Risk of anaphylactic shock
- Possible gallbladder effects
- Blood picture should be checked during prolonged treatment
Use in Special Populations
- Not recommended for neonates if premature or newborn (up to 28 days of age)
Overdose Effects
- No specific antidote
- Symptomatic treatment recommended
Therapeutic Class
- Third generation Cephalosporins
Storage Conditions
- Store vial in a cool, dry place (below 30°C)
- Away from light and moisture
- Keep out of the reach of children