Vertex 500 mg/vial (IV Injection)

500 mg vial: ৳ 130.39

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Orion pharma ltd
Also available as
Vertex 250 mg injection Vertex 1 gm injection Vertex 2 gm injection Vertex 1 gm injection Vertex 250 mg injection Vertex 500 mg injection

Title and Category

  • Vertex Injectable Suspension
  • Pharmaceuticals
  • Third generation Cephalosporins

Color Options

  • No color options available

Dimensions

  • N/A—product is in liquid form

Dosage Forms

  • Intravenous
  • Intramuscular

Treatment Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacological Action

  • Bactericidal activity against a wide range of Gram-positive and Gram-negative organisms
  • Interferes with the synthesis of the bacterial cell wall
  • High degree of stability in the presence of beta lactamases
  • Long plasma elimination half-life of about 6 to 9 hours
  • Not metabolized in the body
  • Highly protein bound (95%)

Usual Adult Dose

  • 1 to 2 gm by intravenous or intramuscular administration once a day (or in equally divided doses twice a day)

Maximum Dose

  • 4 gm/day

Usual Pediatric Dose

  • 50 to 75 mg/kg intravenous or intramuscular administration once a day (or in equally divided doses twice a day)

Maximum Pediatric Dose

  • 2 gm/day

Recommended Duration of Therapy

  • More than 2 days after signs and symptoms of infection have disappeared
  • 4 to 14 days for usual infections

Preparation for Intramuscular/Intravenous Injections

  • Dissolving in Lidocaine HCI 1% injection or Water for injection as per dosage

Administration Time

  • 2-4 minutes for intramuscular or intravenous injection
  • Tubing infusion over a period of 30 minutes

Preparation Shelf-life

  • Potency maintained for at least 6 hours at room temperature or 24 hours at 5°C

Interaction

  • No reported drug interactions

Contraindications

  • Hypersensitivity to cephalosporin antibiotics

Common Side Effects

  • Gastro-intestinal effects (e.g., diarrhea, nausea, vomiting)
  • Cutaneous reactions (e.g., rash, pruritus, urticaria)
  • Hematologic reactions (e.g., eosinophilia, thrombocytopenia)
  • Hepatic reactions (e.g., elevations of SGOT or SGPT)
  • CNS reactions (e.g., nervousness, confusion, sleep disturbances)
  • Local phlebitis

Pregnancy and Lactation

  • Not established safe in pregnancy
  • Excreted in low concentrations in human milk

Precautions and Warnings

  • Anaphylactic shock precaution
  • Regular blood picture check during prolonged treatment

Special Populations

  • Not for neonates if premature and newborn (up to 28 days of age)

Overdose Effects

  • No specific antidote—treatment should be symptomatic

Therapeutic Class

  • Third generation Cephalosporins

Storage Conditions

  • Store in a cool, dry place (below 30°C)
  • Away from light and moisture
  • Keep out of the reach of children

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