Vertex 2 gm/vial (IV Injection)

2 gm vial: ৳ 302.04

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Orion pharma ltd
Also available as
Vertex 250 mg injection Vertex 500 mg injection Vertex 1 gm injection Vertex 1 gm injection Vertex 250 mg injection Vertex 500 mg injection

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

Ceftriaxone is a 3rd generation broad-spectrum parenteral cephalosporin antibiotic with potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. It kills bacteria by interfering with the synthesis of the bacterial cell wall. Ceftriaxone has a relatively long plasma elimination half-life of about 6 to 9 hours, and is highly protein bound (95%).

Dosage

  • Adult: 1 to 2 gm by intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
  • Maximum dose: 4 gm/day
  • Children: 50 to 75 mg/kg intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
  • Usual duration of therapy is 4 to 14 days

Administration

  • Intramuscular Injection:
    • Dissolve 250 mg or 500 mg Ceftriaxone in 2 ml Lidocaine HCI 1% injection
    • Dissolve 1 g Ceftriaxone in 3.5 ml of Lidocaine HCI 1% injection
  • Intravenous Injection:
    • Dissolve 250 mg or 500 mg Ceftriaxone in 5 ml of Water for injection
    • Dissolve 1 g Ceftriaxone in 10 ml of Water for injection USP
    • Dissolve 2 g Ceftriaxone in 20 ml of Water for injection
  • Duration of Solution Stability: Maintains potency for at least 6 hours at room temperature or 24 hours at 5°C

Interaction

No drug interactions reported

Contraindications

Not for patients with a history of hypersensitivity to cephalosporin antibiotics

Side Effects

  • Gastro-intestinal effects
  • Cutaneous reactions
  • Hematologic reactions
  • Hepatic reactions
  • CNS reactions
  • Local phlebitis after intravenous administration

Pregnancy & Lactation

Safety in human pregnancy not established; caution in lactating mothers

Precautions & Warnings

  • Anaphylactic shock potential
  • Sonogram findings related to gallbladder
  • Regular blood picture checks during prolonged treatment

Use in Special Populations

Not for neonates if premature or newborn (up to 28 days of age)

Overdose Effects

No specific antidote. Symptomatic treatment recommended

Therapeutic Class

Third generation Cephalosporins

Storage Conditions

Store vial below 30°C, away from light and moisture

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