Winner 500 mg/vial (IV Injection)

500 mg vial: ৳ 120.45

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Biopharma limited
Also available as
Winner 500 mg injection Winner 1 gm injection Winner 1 gm injection Winner 2 gm injection

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

Ceftriaxone is a 3rd generation broad-spectrum parenteral cephalosporin antibiotic with potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. It kills bacteria by interfering with the synthesis of the bacterial cell wall and has a relatively long plasma elimination half-life of about 6 to 9 hours.

Dosage

  • Usual dose for adults is 1 to 2 gm by intravenous or intramuscular administration once a day
  • Maximum adult dose of 4 gm/day for certain infections
  • Usual dose for infants and children (01 month or older) is 50 to 75 mg/kg intravenous or intramuscular administration once a day
  • Duration of therapy: 4 to 14 days; longer therapy may be required in complicated infections

Administration

  • Preparation of Solutions for Intramuscular / Intravenous Injections using Lidocaine HCI 1% or Water for injection USP
  • Injection should be administered over 2-4 minutes by Intramuscular or Intravenous injection or by tubing infusion over a period of 30 minutes

Interaction

No drug interactions reported

Contraindications

Not to be given to patients with a history of hypersensitivity to cephalosporin antibiotics

Side Effects

  • Gastro-intestinal effects including diarrhea, nausea and vomiting
  • Cutaneous reactions including rash, pruritus, urticaria, edema and erythema multiforme
  • Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia and neutropenia
  • Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
  • CNS reactions including nervousness, confusion, sleep disturbances, headache, hyperactivity, convulsion, hypertonia and dizziness
  • Local phlebitis occurs rarely following intravenous administration but can be minimized by slow injections

Pregnancy & Lactation

Not established for safety in human pregnancy; caution during lactation

Precautions & Warnings

  • Anaphylactic shock cannot be ruled out
  • Shadows suggesting sludge have been detected by sonograms of the gallbladder
  • Blood picture should be checked at regular intervals during prolonged treatment

Use in Special Populations

Must not be given to neonates if premature and newborn (up to 28 days of age)

Overdose Effects

No specific antidote; treatment should be symptomatic

Therapeutic Class

Third generation Cephalosporins

Storage Conditions

Vial store in a cool, dry place (below 30° C), away from light & moisture; keep out of the reach of children

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