Gen4 1 gm/vial (IM/IV Injection)

1 gm vial: ৳ 555.00

Medicine Details

Category Details
Generic Cefepime hydrochloride
Company Ibn sina pharmaceuticals ltd
Also available as
Gen4 500 mg injection

Title

  • Gen4

Categories

  • Medicine
  • Pharmaceuticals

Description

  • Fourth generation cephalosporin indicated for the treatment of various infections caused by susceptible strains of microorganisms.

Indications

  • Treatment of pneumonia (moderate to severe)
  • Treatment of febrile neutropenia
  • Treatment of urinary tract infections (complicated and uncomplicated)
  • Treatment of skin and skin structure infections
  • Treatment of intra-abdominal infections (used in combination with metronidazole)

Pharmacology

  • Bactericidal action
  • Disruption of peptidoglycan layer synthesis in bacterial cell walls
  • Mode of action similar to other beta-lactam antibiotics

Dosage & Administration

  • Administered intravenously over approximately 30 minutes
  • Specific dosage for various infections as per severity level and causative microorganisms

Interaction

  • Monitoring of renal function when administered with aminoglycosides
  • Potential nephrotoxicity and ototoxicity with aminoglycoside antibiotics

Contraindications

  • Immediate hypersensitivity reactions to cefepime or cephalosporin class of antibiotics
  • Hypersensitivity to penicillin or other betalactum antibiotics

Side Effects

  • Immediate hypersensitivity reactions
  • Potential for overgrowth of non-susceptible microorganisms with prolonged use

Pregnancy & Lactation

  • Pregnancy Category B
  • Excretion in human breast milk in very low concentrations
  • Caution advised during lactation

Precautions & Warnings

  • Prescription only in presence of proven or strongly suspected bacterial infection
  • Monitoring of patient's condition during prolonged use
  • Association with fall in prothrombin activity
  • Caution in patients with history of gastrointestinal disease
  • Effects of arginine on glucose metabolism and serum potassium

Use in Special Populations

  • Pediatric use up to 16 years with maximum recommended dose
  • Caution in geriatric patients with renal insufficiency
  • No dose adjustment for impaired hepatic function
  • Dose adjustment for impaired renal function

Overdose Effects

  • Careful observation and supportive treatment for patients
  • Recommendation of hemodialysis in case of renal insufficiency
  • Symptoms include encephalopathy, myoclonus, seizures, and neuromuscular excitability

Therapeutic Class

  • Fourth generation Cephalosporins

Reconstitution

  • Intravenous and intramuscular administration
  • Compatibility with various diluents and IV infusion fluids
  • Specific details for reconstitution of different vial strengths

Storage Conditions

  • Expiry date adherence
  • Medicine safety around children
  • Dispensing only on registered physician's prescription

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