Japime 1 gm/vial (IM/IV Injection)

1 gm vial: ৳ 551.65

Medicine Details

Category Details
Generic Cefepime hydrochloride
Company Jayson pharmaceuticals ltd

Indications

  • Treatment of moderate to severe pneumonia
  • Empiric treatment of febrile neutropenic patients
  • Treatment of uncomplicated and complicated urinary tract infections
  • Treatment of uncomplicated skin and skin structure infections
  • Treatment of complicated intra-abdominal infections
  • Bactericidal mode of action
  • Disruption of peptidoglycan layer of bacterial cell walls
  • Compatible with intravenous administration
  • Excreted in human breast milk in low concentrations
  • Use in pediatric patients
  • Use in geriatric patients
  • Use in patients with impaired hepatic function
  • Use in patients with impaired renal function
  • Symptoms of overdose include encephalopathy, myoclonus, seizures
  • Therapeutic class - Fourth generation cephalosporins
  • Reconstitution with sterile water for injection
  • Reconstitution with intravenous infusion fluids
  • Reconstitution with intramuscular diluents
  • Storage conditions - do not use after expiry date

Dosage & Administration

  • Intravenous administration over approximately 30 minutes
  • Specific dosages for different types of infections
  • Dose adjustment in patients with impaired renal function
  • Dose adjustment in pediatric patients
  • Dose adjustment in geriatric patients
  • Maximum pediatric dose should not exceed recommended adult dose
  • Different volumes of sterile water for injection for reconstitution

Interaction

  • Monitoring of renal function when administering with aminoglycosides
  • Nephrotoxicity with concomitant administration of cephalosporins and potent diuretics

Contraindications

  • Immediate hypersensitivity reactions to cefepime or cephalosporin class
  • Contraindicated in patients with penicillin allergy
  • Contraindicated in patients with beta-lactam antibiotic allergy

Side Effects

  • Immediate hypersensitivity reactions

Pregnancy & Lactation

  • Pregnancy category B
  • Caution in use during pregnancy
  • Excretion in human breast milk
  • Caution in use during lactation

Precautions & Warnings

  • Avoid prescribing in absence of proven or strongly suspected bacterial infection
  • Monitoring for overgrowth of non-susceptible microorganisms
  • Prothrombin time monitoring in at-risk patients
  • Caution in individuals with a history of gastrointestinal disease
  • Arginine may alter glucose metabolism and elevate serum potassium

Use in Special Populations

  • Maximum dose for pediatric patients
  • Geriatric patients with renal insufficiency at risk of serious adverse events
  • No dose adjustment necessary for impaired hepatic function
  • Dose adjustment for impaired renal function

Overdose Effects

  • Careful observation and supportive treatment
  • Hemodialysis recommended in the presence of renal insufficiency
  • Symptoms include encephalopathy, myoclonus, seizures

Reconstitution

  • Intravenous administration
  • Intravenous compatibility with specific fluids
  • Intramuscular administration
  • Specific volumes of sterile water for injection for reconstitution

Storage Conditions

  • Do not use after expiry date
  • Keep out of reach of children
  • Dispense only on prescription of a registered physician

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