Megapime 1 gm/vial (IM/IV Injection)
1 gm vial: ৳ 550.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Cefepime hydrochloride |
| Company | Eskayef pharmaceuticals ltd |
| Also available as |
Title and Categories
- Megapime
- Fourth Generation Cephalosporins
Indications
- Treatment of moderate to severe pneumonia caused by Streptococcus pneumoniae, Pseudomonas aeruginosa, Klebsiella pneumoniae, or Enterobacter species
- Empiric treatment of febrile neutropenic patients
- Treatment of uncomplicated and complicated urinary tract infections, including pyelonephritis
- Treatment of uncomplicated skin and skin structure infections
- Treatment of complicated intra-abdominal infections (used in combination with metronidazole)
Pharmacology
- Bactericidal action
- Disruption of peptidoglycan layer synthesis in bacterial cell walls
Dosage and Administration
- Administered intravenously over approximately 30 minutes
- Specific dosage for different types of infections
Interaction
- Increased potential of nephrotoxicity and ototoxicity when administered with high doses of aminoglycosides
- Nephrotoxicity reported with concomitant administration of other cephalosporins with potent diuretics
Contraindications
- Immediate hypersensitivity reactions to cefepime or the cephalosporin class of antibiotics
- Hypersensitivity reactions to penicillin or other betalactum antibiotics
Side Effects
- Potential occurrence of hypersensitivity reactions
Pregnancy and Lactation
- Pregnancy Category B
- Excretion in breast milk in very low concentrations
- Caution advised during administration to nursing woman
Precautions and Warnings
- Avoid prescribing in the absence of proven or strongly suspected bacterial infection
- Risk of overgrowth of non susceptible microorganisms with prolonged use
- Association with fall in prothrombin activity
- Caution in patients with gastrointestinal disease
- Effect of arginine on glucose metabolism and serum potassium levels
Use in Special Populations
- Maximum dose for pediatric patients should not exceed recommended adult dose
- Dosage recommendations for pediatric patients based on weight
- Serious adverse events reported in geriatric patients with renal insufficiency
- No adjustment necessary for patients with impaired hepatic function
- Dose adjustment necessary for patients with impaired renal function
Overdose Effects
- Careful observation and supportive treatment for patients who receive an overdose
- Recommended hemodialysis in the presence of renal insufficiency
Reconstitution
- Recommended method for intravenous and intramuscular administration
- Compatibility with various IV infusion fluids
- Specific reconstitution instructions for different vial sizes
Storage Conditions
- Expiry date consideration
- Keep out of reach of children
- Dispense only on prescription of a registered physician